2. Gene
  3. ZFYVE16 - zinc finger FYVE-type containing 16 Gene

ZFYVE16 - zinc finger FYVE-type containing 16 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含锌指 FYVE 型 16

种属: Homo sapiens

同用名: PPP1R69

基因 ID: 9765 | 基因类型: protein coding

关于 ZFYVE16

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:80,407,610-80,483,379 (from NCBI)

This gene has 13 transcripts (splice variants), 95 orthologues and 13 paralogues. Ubiquitous expression in brain (RPKM 10.1), endometrium (RPKM 9.9) and 25 other tissues.

功能概要

该基因编码属于 FYVE 锌指蛋白家族的内体蛋白。编码的蛋白质被认为调节核内体中的膜运输。该蛋白在转化生长因子-β信号通路中起支架蛋白的作用，参与骨形态发生蛋白信号通路的正负反馈调节。交替剪接导致多个转录本变体。[RefSeq 提供，2013 年 9 月]

This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

ZFYVE16 基因产物(5)

mRNA Protein Name
NM_001105251.4 NP_001098721.2 zinc finger FYVE domain-containing protein 16 isoform a
NM_001284236.3 NP_001271165.2 zinc finger FYVE domain-containing protein 16 isoform a
NM_001284237.2 NP_001271166.2 zinc finger FYVE domain-containing protein 16 isoform b
NM_001349434.2 NP_001336363.2 zinc finger FYVE domain-containing protein 16 isoform a
NM_014733.6 NP_055548.4 zinc finger FYVE domain-containing protein 16 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-phosphatidylinositol binding IDA
IDA: 通过直接分析推断
11546807 GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: 通过直接分析推断
11433298 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14613930 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endosomal transport IMP
IMP: 通过突变表型推断
11546807 GOA
involved in protein targeting to lysosome IMP
IMP: 通过突变表型推断
11546807 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in early endosome IDA
IDA: 通过直接分析推断
11546807 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZFYVE16 蛋白结构

FYVE

FYVE: FYVE zinc finger (743 - 805)

DUF3480

DUF3480: Domain of unknown function (DUF3480) (1167 - 1515)

  • 0
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  • 1200
  • 1539 a.a.
蛋白主名 其他名称

zinc finger FYVE domain-containing protein 16

endosome-associated FYVE-domain protein

ZFYVE16 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZFYVE16 Q7Z3T8 EEA1 Homo sapiens Q15075
Density Sedimentation
14613930
种属内
ZFYVE16 Q7Z3T8 PPP1CA Homo sapiens P62136
Y2H
15231748
种属内
ZFYVE16 Q7Z3T8 TOM1 Homo sapiens O60784
Pull Down
14613930
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation

Intracranial Arteriovenous Malformation

Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To

Intracranial Arteriovenous Malformations

Bavm

Cerebral Arteriovenous Malformations

Intracranial Hemorrhage In Brain Cerebrovascular Malformations

Arteriovenous Malformation Of The Brain, Somatic

Intracranial Avm

Arteriovenous Malformations Cerebral
Gluten Allergy

Allergy To Gluten

Gluten Allergic Reaction
Psoriasis 14, Pustular

Generalized Pustular Psoriasis

Gpp

Ditra

Acrodermatitis Continua Of Hallopeau

Palmoplantar Pustulosis

PSORS14

Interleukin 36 Receptor Antagonist Deficiency

Psorp

Pustular Psoriasis 14

Deficiency Of Il-36r Antagonist

Acute Generalised Pustular Psoriasis

Deficiency Of The Interleukin-36 Receptor Antagonist

Generalized Pustular Psoriasis Of Von Zumbusch

Von Zumbusch Psoriasis

Deficiency Of Il-36ra

Psoriasis, Pustular, Generalized

Psoriasis, Pustular, Type 14

Pustulosis Of Palms And Soles

Acute Generalized Pustular Psoriasis

Palmoplantar Pustular Psoriasis

Pustulosis Palmaris Et Plantaris

Ppp - [Palmoplantar Pustulosis]

Pustular Psoriasis Of The Palms And Soles

Pustular Bacterid
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16056 ZFYVE16 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ZFYVE16 VGNC VGNC:79281
Mus musculus ZFYVE16 MGD MGI:2145181
Canis familiaris ZFYVE16 VGNC VGNC:48623
Bos taurus ZFYVE16 VGNC VGNC:37174
Rattus norvegicus ZFYVE16 RGD RGD:1564784
Felis catus ZFYVE16 VGNC VGNC:67238
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