1. Gene
  2. TOM1 - target of myb1 membrane trafficking protein Gene

TOM1 - target of myb1 membrane trafficking protein Gene

中文名称:myb1 膜运输蛋白的目标

种属: Homo sapiens

同用名: IMD85

基因 ID: 10043 | 基因类型: protein coding

关于 TOM1

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:35,299,275-35,347,973 (from NCBI)

This gene has 18 transcripts (splice variants), 221 orthologues, 10 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 24.4), esophagus (RPKM 24.1) and 25 other tissues.

功能概要

该基因被鉴定为 v-myb 致癌基因的靶标。编码的蛋白质与核内体囊泡运输相关的蛋白质共享其 N 末端结构域。它通过与内毒素的相互作用被募集到内体。已经为该基因发现了几种编码不同亚型的可变剪接转录物变体。[RefSeq 提供,2008 年 10 月]

This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

TOM1 基因产物(4)

mRNA Protein Name
NM_001135729.2 NP_001129201.1 target of Myb1 membrane trafficking protein isoform 3
NM_001135730.2 NP_001129202.1 target of Myb1 membrane trafficking protein isoform 4
NM_001135732.2 NP_001129204.1 target of Myb1 membrane trafficking protein isoform 2
NM_005488.3 NP_005479.1 target of Myb1 membrane trafficking protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables clathrin binding IDA
IDA: 通过直接分析推断
16412388 GOA
enables clathrin heavy chain binding IDA
IDA: 通过直接分析推断
14563850 GOA
enables myosin VI binding IDA
IDA: 通过直接分析推断
23023224 GOA
enables phosphatidylinositol-5-phosphate binding IDA
IDA: 通过直接分析推断
25588840 GOA
enables polyubiquitin modification-dependent protein binding IDA
IDA: 通过直接分析推断
14563850 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14563850 GOA
enables ubiquitin binding IDA
IDA: 通过直接分析推断
16199040 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in autophagosome-lysosome fusion IMP
IMP: 通过突变表型推断
23023224 GOA
involved in endosomal transport IDA
IDA: 通过直接分析推断
14563850 GOA
involved in positive regulation of autophagosome maturation IMP
IMP: 通过突变表型推断
23023224 GOA
involved in regulation of endosome organization IDA
IDA: 通过直接分析推断
25588840 GOA
involved in substrate localization to autophagosome IMP
IMP: 通过突变表型推断
23023224 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
14563850 GOA
located in cytosol IDA
IDA: 通过直接分析推断
14613930 GOA
located in early endosome IDA
IDA: 通过直接分析推断
14613930 GOA
located in endosome IDA
IDA: 通过直接分析推断
15047686 GOA
located in endosome membrane IDA
IDA: 通过直接分析推断
23023224 GOA
located in membrane IDA
IDA: 通过直接分析推断
14613930 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TOM1 蛋白结构

VHS

VHS: VHS domain (8 - 148)

GAT

GAT: GAT domain (213 - 311)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 492 a.a.
蛋白主名 其他名称

target of Myb1 membrane trafficking protein

target of Myb protein 1

target of myb 1

TOM1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TOM1 O60784 TOLLIP Homo sapiens Q6FIE9
Validated Y2H
25416956
种属内
TOM1 O60784 TOLLIP Homo sapiens Q6FIE9
Y2H Array
25416956
种属内
TOM1 O60784 TOLLIP Homo sapiens Q9H0E2-1
Solution Sedimentation
26320582
种属内
TOM1 O60784 TOLLIP Homo sapiens Q9H0E2-1
NMR
26320582
种属内
TOM1 O60784 TOLLIP Homo sapiens Q9H0E2-1
SPR
26320582
种属内
TOM1 O60784 ZFYVE16 Homo sapiens Q7Z3T8
Y2H
14613930
种属内
TOM1 O60784 ZFYVE16 Homo sapiens Q7Z3T8
Anti Tag CoIP
14613930
种属内
TOM1 O60784 ZFYVE16 Homo sapiens Q7Z3T8
Density Sedimentation
14613930
种属内
TOM1 O60784 ZFYVE16 Homo sapiens Q7Z3T8
Anti Tag CoIP
33961781
种属内
TOM1 O60784 ZFYVE16 Homo sapiens Q7Z3T8
Anti Bait CoIP
14613930
种属内
TOM1 O60784 TOLLIP Homo sapiens Q9H0E2
Anti Tag CoIP
33961781
种属内
TOM1 O60784 TOLLIP Homo sapiens Q9H0E2
Y2H Array
31515488
种属内
TOM1 O60784 TOLLIP Homo sapiens Q9H0E2
Y2H Prey Pooling
25416956
种属内
TOM1 O60784 TOLLIP Homo sapiens Q9H0E2
CoIP
14563850
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Immunodeficiency 85 And Autoimmunity

IMD85

Immunodeficiency 85

Immunodeficiency 31c

IMD31C

Candidiasis, Familial, 7

Candf7

Candidiasis, Familial Chronic Mucocutaneous, Autosomal Dominant

Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome

Autoimmune Enteropathy And Endocrinopathy - Susceptibility To Chronic Infections Syndrome

Immunodeficiency 31c, Chronic Mucocutaneous Candidiasis, Autosomal Dominant

Autosomal Dominant Chronic Mucocutaneous Familial Candidiasis

Autosomal Dominant Immunodeficiency 31c

Familial Candidiasis 7

Chronic Mucocutaneous Candidiasis 7

Immunodeficiency 31c, Autosomal Dominant

Immunodeficiency, Type 31c, Autosomal Dominant

Autoimmune Enteropathy
Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia

X-Linked Nephrolithiasis Type I

Nephrolithiasis 1

Nephrolithiasis X-Linked Recessive Type 1

Nphl1

X-Linked Nephrolithiasis With Renal Failure

X-Linked Recessive Urolithiasis Type 1

Xrn

Congenital Muscular Dystrophy-Dystroglycanopathy Type A6

Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies Type A6

Mddga6

Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease, Large-Related

Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies, Type A6

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus TOM1 VGNC VGNC:66441
Macaca mulatta TOM1 VGNC VGNC:78615
Mus musculus TOM1 MGD MGI:1338026
Rattus norvegicus TOM1 RGD RGD:1308024
Canis familiaris TOM1 VGNC VGNC:47707
Bos taurus TOM1 VGNC VGNC:36217