2. Gene
  3. EEA1 - early endosome antigen 1 Gene

EEA1 - early endosome antigen 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：早期内体抗原 1

种属: Homo sapiens

同用名: MST105; ZFYVE2; MSTP105

基因 ID: 8411 | 基因类型: protein coding

关于 EEA1

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:92,770,637-92,929,295 (from NCBI)

This gene has 5 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in esophagus (RPKM 9.9), fat (RPKM 8.8) and 25 other tissues.

功能概要

启用 1-磷脂酰肌醇结合活性； GTP 依赖性蛋白结合活性；和蛋白质同二聚化活性。参与内吞作用；囊泡融合；和病毒 RNA 基因组复制。位于胞质溶胶和早期内体。是质膜的外在成分。 [由基因组资源联盟提供，2022 年 4 月]

Enables 1-phosphatidylinositol binding activity; GTP-dependent protein binding activity; and protein homodimerization activity. Involved in endocytosis; vesicle fusion; and viral RNA genome replication. Located in cytosol and early endosome. Is extrinsic component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

EEA1 基因产物(1)

mRNA Protein Name
NM_003566.4 NP_003557.3 early endosome antigen 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-phosphatidylinositol binding IDA
IDA: 通过直接分析推断
11256955 GOA
enables GTP-dependent protein binding IDA
IDA: 通过直接分析推断
10491193 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9697774 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
11741531 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endocytosis IMP
IMP: 通过突变表型推断
21081650 GOA
involved in modulation by host of viral process IMP
IMP: 通过突变表型推断
19376974 GOA
involved in vesicle fusion IMP
IMP: 通过突变表型推断
9697774 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
7768953 GOA
located in early endosome IDA
IDA: 通过直接分析推断
11741531 GOA
located in early endosome membrane IDA
IDA: 通过直接分析推断
7768953 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

early endosome antigen 1

early endosome antigen 1, 162kD

EEA1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EEA1 Q15075 RAB5C Homo sapiens P51148
SPR
25114243
种属内
EEA1 Q15075 RAB5C Homo sapiens P51148
Confocal
25266290
种属内
EEA1 Q15075 SAMD9 Homo sapiens Q5K651
Anti Tag CoIP
24029230
种属内
EEA1 Q15075 ZFYVE16 Homo sapiens Q7Z3T8
BioID
29568061
种属内
EEA1 Q15075 RAB5B Homo sapiens P61020
Pull Down
10491193
种属内
EEA1 Q15075 RAB5A Homo sapiens P20339
Pull Down
16902405
种属内
EEA1 Q15075 RAB5A Homo sapiens P20339
Pull Down
11870209
种属内
EEA1 Q15075 RAB22A Homo sapiens Q9UL26
Pull Down
11870209
种属内
EEA1 Q15075 RAB22A Homo sapiens Q9UL26
Y2H
11870209
种属内
EEA1 Q15075 ERBB2 Homo sapiens P04626
Anti Bait CoIP
16314522
种属间
EEA1 Q15075 Stx6 Rattus norvegicus Q63635
Pull Down
10506127
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Subacute Cutaneous Lupus Erythematosus

Lupus Erythematosus Cutaneous Subacute

Lupus Erythematosus, Subacute Cutaneous

Sacle - [Subacute Cutaneous Lupus Erythematosus]

Scle - [Subacute Cutaneous Lupus Erythematosus]
Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous
Oculoglandular Tularemia
Human Monocytic Ehrlichiosis

Ehrlichiosis Chafeensis

Hme

Human Ehrlichial Infection, Human Monocytic Type
Human Granulocytic Anaplasmosis

Human Granulocytic Ehrlichiosis

Hge

Human Ehrlichial Infection, Human Granulocytic Type

Human Anaplasmosis Due To Anaplasma Phagocytophilum
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
Hermansky-Pudlak Syndrome

Hps

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Hermanski-Pudlak Syndrome

Hermansky Pudlak Syndrome

Platelet Storage Pool Deficiency
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia
Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-150058 Bocconoline ≥95.0% 否
HY-RS04172 EEA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus EEA1 VGNC VGNC:54421
Felis catus EEA1 VGNC VGNC:61730
Mus musculus EEA1 MGD MGI:2442192
Rattus norvegicus EEA1 RGD RGD:1310167
Canis familiaris EEA1 VGNC VGNC:40205
Macaca mulatta EEA1 VGNC VGNC:72161
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