PPP1R13L - protein phosphatase 1 regulatory subunit 13 like Gene

中文名称：蛋白磷酸酶 1 调节亚基 13 样

种属: Homo sapiens

同用名: RAI; RAI4; IASPP; NKIP1

基因 ID: 10848 | 基因类型: protein coding

关于 PPP1R13L

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,379,638-45,406,361 (from NCBI)

This gene has 9 transcripts (splice variants), 174 orthologues and is associated with 1 phenotype. Broad expression in skin (RPKM 27.0), placenta (RPKM 6.4) and 14 other tissues.

功能概要

IASPP 是进化上最保守的 p53 抑制剂之一 (TP53；MIM 191170) ，而 ASPP1 (MIM 606455) 和 ASPP2 (MIM 602143) 是 p53 的激活剂。[OMIM 提供，2008 年 3 月]

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

PPP1R13L 基因产物(2)

mRNA	Protein	Name
NM_001142502.2	NP_001135974.1	relA-associated inhibitor
NM_006663.4	NP_006654.2	relA-associated inhibitor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	18275817	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17906639	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of inflammatory response	IMP IMP: 通过突变表型推断	28069640	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP1R13L 蛋白结构

Ank_2

SH3_9

0
200
400
600
828 a.a.

蛋白主名

其他名称

relA-associated inhibitor

NFkB interacting protein 1

PPP1R13L 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PPP1R13L	Q8WUF5	RAN	Homo sapiens	P62826	Pull Down	24855949
种属内	PPP1R13L	Q8WUF5	RAN	Homo sapiens	P62826	SPR	24855949
种属内	PPP1R13L	Q8WUF5	PPP1CB	Homo sapiens	P62140	Anti Tag CoIP	21998301
种属内	PPP1R13L	Q8WUF5	PPP1CB	Homo sapiens	P62140	Anti Tag CoIP	33961781
种属内	PPP1R13L	Q8WUF5	PPP1CA	Homo sapiens	P62136	Anti Bait CoIP	21998301
种属内	PPP1R13L	Q8WUF5	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	21998301
种属内	PPP1R13L	Q8WUF5	TP53	Homo sapiens	P04637	Anti Bait CoIP	17906639
种属内	PPP1R13L	Q8WUF5	TP53	Homo sapiens	P04637	Anti Bait CoIP	23623661
种属内	PPP1R13L	Q8WUF5	TP53	Homo sapiens	P04637	Anti Bait CoIP	21513714
种属内	PPP1R13L	Q8WUF5	TP53	Homo sapiens	P04637	Solid Phase Assay	18275817
种属内	PPP1R13L	Q8WUF5	TP53	Homo sapiens	P04637	IF	23623661
种属内	PPP1R13L	Q8WUF5	EP300	Homo sapiens	Q09472	Anti Bait CoIP	21513714
种属间	PPP1R13L	Q8WUF5	Q9WMX2-PRO_0000037551	Hepatitis C virus	Q9WMX2-PRO_0000037551	Y2H Prey Pooling	18985028
种属间	PPP1R13L	Q8WUF5	Q9WMX2-PRO_0000037551	Hepatitis C virus	Q9WMX2-PRO_0000037551	Pull Down	18985028

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Multiple Congenital Anomalies/Dysmorphic Syndrome

Noonan Syndrome With Multiple Lentigines

Leopard Syndrome	Multiple Lentigines Syndrome
Moynahan Syndrome	Cardiomyopathic Lentiginosis
Progressive Cardiomyopathic Lentiginosis	Cardio-Cutaneous Syndrome
Lentiginosis Profusa	Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome
Generalized Lentiginosis	Gorlin Syndrome Ii
Lentiginosis Profusa Syndrome	Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes
Diffuse Lentiginosis	Nsml
Familial Multiple Lentigines Syndrome	Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type
Progressive Cardiomyopathic Lentiginosis Syndrome	Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Testicular Cancer

Testis Cancer	Testicular Carcinoma
Testicular Neoplasms	Malignant Neoplasm Of Testis
Childhood Neoplasm Of The Testis	Neoplasm Of Testis
Pediatric Testicular Neoplasm	Testicular Tumor
Testis Neoplasm	Testicular Tumors
Testicular Neoplasm	Testicular Malignant Germ Cell Tumor
Childhood Testicular Neoplasm	Carcinoma Of The Testis
Cancer Of Testis	Malignant Neoplasm Of Testis, Nos
Malignant Neoplasm Of Testis, Unspecified	Malignant Tumour Of Testis
Testicle Cancer	Primary Malignant Neoplasm Of Testis

Spinal Chordoma

Chordoma Of Spine

Vertebral Chordoma

Smith-Magenis Syndrome

SMS	Chromosome 17p11.2 Deletion Syndrome
17p11.2 Microdeletion Syndrome	17p11.2 Monosomy
Chromosome 17p Deletion Syndrome	Del(17)
P11.2	17p- Syndrome
Deletion 17p Syndrome	Partial Monosomy 17p

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10982	PPP1R13L Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PPP1R13L	RGD	RGD:1593681
Bos taurus	PPP1R13L	VGNC	VGNC:33225
Mus musculus	PPP1R13L	MGD	MGI:3525053
Canis familiaris	PPP1R13L	VGNC	VGNC:44882

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PPP1R13L - protein phosphatase 1 regulatory subunit 13 like Gene

关于 PPP1R13L

功能概要

PPP1R13L 基因产物(2)

PPP1R13L 蛋白结构

PPP1R13L 蛋白互作信息

关联疾病

直系同源

热门区域

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PPP1R13L - protein phosphatase 1 regulatory subunit 13 like Gene

关于 PPP1R13L

功能概要

PPP1R13L 基因产物(2)

PPP1R13L 蛋白结构

PPP1R13L 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z