2. Gene
  3. PPP1R10 - protein phosphatase 1 regulatory subunit 10 Gene

PPP1R10 - protein phosphatase 1 regulatory subunit 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白磷酸酶 1 调节亚基 10

种属: Homo sapiens

同用名: p99; FB19; R111; CAT53; PNUTS; PP1R10

基因 ID: 5514 | 基因类型: protein coding

关于 PPP1R10

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,600,413-30,617,243 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 196 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 17.1), adrenal (RPKM 16.4) and 25 other tissues.

功能概要

该基因编码蛋白磷酸酶 1 结合蛋白。编码的蛋白质通过调节蛋白磷酸酶 1 的活性在许多细胞过程中发挥作用，包括细胞周期进程、DNA 修复和细胞凋亡。该基因位于 6 号染色体上的主要组织相容性复合体 I 类区域，选择性剪接的转录变体已被观察到这个基因。[RefSeq 提供，2012 年 7 月]

This gene encodes a protein Phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and Apoptosis by regulating the activity of protein Phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

PPP1R10 基因产物(2)

mRNA Protein Name
NM_001376195.1 NP_001363124.1 serine/threonine-protein phosphatase 1 regulatory subunit 10
NM_002714.4 NP_002705.2 serine/threonine-protein phosphatase 1 regulatory subunit 10
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15231748 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cardiac muscle cell apoptotic process IDA
IDA: 通过直接分析推断
23426265 GOA
involved in negative regulation of mitotic DNA damage checkpoint IGI
IGI: 通过遗传相互作用推断
23426265 GOA
involved in positive regulation of telomere maintenance IMP
IMP: 通过突变表型推断
23426265 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with chromosome, telomeric region IDA
IDA: 通过直接分析推断
24270157 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP1R10 蛋白结构

Med26

Med26: TFIIS helical bundle-like domain (94 - 144)

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (909 - 932)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 940 a.a.
蛋白主名 其他名称

serine/threonine-protein phosphatase 1 regulatory subunit 10

HLA-C associated transcript 53

PPP1R10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PPP1R10 Q96QC0 PPP1CA Homo sapiens P62136
Y2H
15231748
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Adrenal Gland Pheochromocytoma

Pheochromocytoma
Hypermethioninemia Due To Adenosine Kinase Deficiency

Adk Hypermethioninemia

Hypermethioninemia Encephalopathy Due To Adenosine Kinase Deficiency

Hypermethioninemia Encephalopathy Due To Adk Deficiency

Mrt8

Mental Retardation, Autosomal Recessive 8, Formerly

Mrt8, Formerly

HMAKD

Mental Retardation, Autosomal Recessive 8
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10976 PPP1R10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PPP1R10 VGNC VGNC:33221
Rattus norvegicus PPP1R10 RGD RGD:620079
Mus musculus PPP1R10 MGD MGI:1289273
Canis familiaris PPP1R10 VGNC VGNC:44876
Macaca mulatta PPP1R10 VGNC VGNC:76367
Felis catus PPP1R10 VGNC VGNC:68999
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