1. Gene
  2. PHACTR3 - phosphatase and actin regulator 3 Gene

PHACTR3 - phosphatase and actin regulator 3 Gene

中文名称:磷酸酶和肌动蛋白调节因子 3

种属: Homo sapiens

同用名: H17739; SCAPIN1; PPP1R123; SCAPININ; C20orf101

基因 ID: 116154 | 基因类型: protein coding

关于 PHACTR3

Cytogenetic location: 20q13.32-q13.33 Genomic coordinates (GRCh38): 20:59,577,509-59,847,711 (from NCBI)

This gene has 9 transcripts (splice variants), 273 orthologues and 3 paralogues. Biased expression in brain (RPKM 9.3), spleen (RPKM 1.0) and 2 other tissues.

功能概要

该基因编码磷酸酶和肌动蛋白调节蛋白家族的成员。编码的蛋白质与增殖细胞中的核支架相关,并与肌动蛋白和蛋白磷酸酶-1 的催化亚基结合,表明它作为蛋白磷酸酶-1 的调节亚基发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供,2013 年 7 月]

This gene encodes a member of the Phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it functions as a regulatory subunit of protein phosphatase-1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

PHACTR3 基因产物(6)

mRNA Protein Name
NM_001199505.1 NP_001186434.1 phosphatase and actin regulator 3 isoform 4
NM_001199506.2 NP_001186435.1 phosphatase and actin regulator 3 isoform 2
NM_001281507.2 NP_001268436.1 phosphatase and actin regulator 3 isoform 2
NM_080672.5 NP_542403.1 phosphatase and actin regulator 3 isoform 1
NM_183244.2 NP_899067.1 phosphatase and actin regulator 3 isoform 2
NM_183246.2 NP_899069.1 phosphatase and actin regulator 3 isoform 3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PHACTR3 蛋白结构

RPEL

RPEL: RPEL repeat (440 - 464)

RPEL

RPEL: RPEL repeat (478 - 500)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 559 a.a.
蛋白主名 其他名称

phosphatase and actin regulator 3

protein phosphatase 1, regulatory subunit 123

PHACTR3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PHACTR3 Q96KR7 CAPNS2 Homo sapiens Q96L46
Validated Y2H
32296183
种属内
PHACTR3 Q96KR7 UBIAD1 Homo sapiens Q9Y5Z9
Validated Y2H
32296183
种属内
PHACTR3 Q96KR7 PPP1CB Homo sapiens P62140
Y2H Array
32296183
种属内
PHACTR3 Q96KR7 PPP1CB Homo sapiens P62140
Y2H Prey Pooling
32296183
种属内
PHACTR3 Q96KR7 UBL5 Homo sapiens Q9BZL1
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Inflammatory Bowel Disease 9

IBD9

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus PHACTR3 MGD MGI:1921439
Rattus norvegicus PHACTR3 RGD RGD:1303029
Felis catus PHACTR3 VGNC VGNC:64130
Canis familiaris PHACTR3 VGNC VGNC:44474
Bos taurus PHACTR3 VGNC VGNC:57015
Macaca mulatta PHACTR3 VGNC VGNC:75805