2. Gene
  3. WDR25 - WD repeat domain 25 Gene

WDR25 - WD repeat domain 25 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：WD 重复域 25

种属: Homo sapiens

同用名: C14orf67

基因 ID: 79446 | 基因类型: protein coding

关于 WDR25

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:100,376,485-100,530,303 (from NCBI)

This gene has 11 transcripts (splice variants), 193 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 3.8), testis (RPKM 2.7) and 25 other tissues.

功能概要

该基因编码含有 7 个 WD 重复序列的蛋白质。 WD 重复是大约 30 到 40 个氨基酸结构域，包含几个保守残基，通常在 C 末端具有色氨酸-天冬氨酸二肽 (WD) 。 WD 结构域参与多种细胞过程中的蛋白质-蛋白质相互作用，包括细胞周期进程、信号转导、细胞凋亡和基因调控。可变剪接导致多个转录本变体。[RefSeq 提供，2017 年 4 月]

This gene encodes a protein containing 7 WD repeats. WD repeats are approximately 30 to 40-amino acid domains containing several conserved residues, typically having a Tryptophan-Aspartic acid dipeptide (WD) at the C-terminal end. WD domains are involved in protein-protein interactions in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

WDR25 基因产物(6)

mRNA Protein Name
NM_001161476.3 NP_001154948.1 WD repeat-containing protein 25 isoform a
NM_001350947.2 NP_001337876.1 WD repeat-containing protein 25 isoform a
NM_001350948.2 NP_001337877.1 WD repeat-containing protein 25 isoform a
NM_001350949.2 NP_001337878.1 WD repeat-containing protein 25 isoform b
NM_001387351.1 NP_001374280.1 WD repeat-containing protein 25 isoform b
NM_024515.6 NP_078791.3 WD repeat-containing protein 25 isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

WDR25 蛋白结构

WD40

WD40: WD domain, G-beta repeat (237 - 277)

WD40

WD40: WD domain, G-beta repeat (282 - 314)

WD40

WD40: WD domain, G-beta repeat (479 - 500)

WD40

WD40: WD domain, G-beta repeat (510 - 544)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 544 a.a.
蛋白主名 其他名称

WD repeat-containing protein 25

epididymis secretory sperm binding protein

关联疾病

疾病名称 别名
Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma

DMSMFH

Bone Dysplasia With Medullary Fibrosarcoma

Bdmf

Bone Dysplasia With Malignant Fibrous Histiocytoma

Hardcastle Syndrome

Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome

Myopathy, Limb-Girdle, With Bone Fragility

Bone Dysplasia-Medullary Fibrosarcoma Syndrome

Diaphyseal Medullary Stenosis-Malignant Fibrous Histiocytoma Syndrome

Dms-Mfh

Limb-Girdle Myopathy With Bone Fragility

Stenosis, Medullary, Diaphyseal, With Malignant Fibrous Histiocytoma
Rapidly Involuting Congenital Hemangioma

Rich
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15769 WDR25 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus WDR25 VGNC VGNC:36888
Felis catus WDR25 VGNC VGNC:67022
Macaca mulatta WDR25 VGNC VGNC:78420
Canis familiaris WDR25 VGNC VGNC:48357
Rattus norvegicus WDR25 RGD RGD:1562505
Mus musculus WDR25 MGD MGI:3045255
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