2. Gene
  3. CCT7 - chaperonin containing TCP1 subunit 7 Gene

CCT7 - chaperonin containing TCP1 subunit 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含伴侣蛋白的 TCP1 亚基 7

种属: Homo sapiens

同用名: CCTH; CCTETA; NIP7-1; TCP1ETA

基因 ID: 10574 | 基因类型: protein coding

关于 CCT7

Cytogenetic location: 2p13.2 Genomic coordinates (GRCh38): 2:73,234,308-73,253,005 (from NCBI)

This gene has 16 transcripts (splice variants), 231 orthologues and 13 paralogues. Ubiquitous expression in testis (RPKM 102.9), adrenal (RPKM 73.8) and 25 other tissues.

功能概要

该基因编码分子伴侣，它是包含 TCP1 复合物 (CCT) 的伴侣蛋白的成员，也称为 TCP1 环复合物 (TRiC) 。该复合物由两个相同的堆叠环组成，每个环包含八种不同的蛋白质。未折叠的多肽进入复合物的中央空腔，并以依赖 ATP 的方式折叠。该复合物折叠各种蛋白质，包括肌动蛋白和微管蛋白。可变剪接导致多个转录本变体。已在 5 号和 6 号染色体上鉴定出相关的假基因。[RefSeq 提供，2009 年 10 月]

This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]

CCT7 基因产物(4)

mRNA Protein Name
NM_001009570.3 NP_001009570.1 T-complex protein 1 subunit eta isoform b
NM_001166284.2 NP_001159756.1 T-complex protein 1 subunit eta isoform c
NM_001166285.2 NP_001159757.1 T-complex protein 1 subunit eta isoform d
NM_006429.4 NP_006420.1 T-complex protein 1 subunit eta isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14532270 GOA
enables protein folding chaperone IDA
IDA: 通过直接分析推断
25467444 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chaperone mediated protein folding independent of cofactor IMP
IMP: 通过突变表型推断
25467444 GOA
involved in chaperone-mediated protein folding IDA
IDA: 通过直接分析推断
22133715 GOA
acts upstream of positive regulation of telomere maintenance via telomerase IMP
IMP: 通过突变表型推断
25467444 GOA
involved in protein folding IDA
IDA: 通过直接分析推断
30955883 GOA
involved in protein stabilization IMP
IMP: 通过突变表型推断
25467444 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of chaperonin-containing T-complex IDA
IDA: 通过直接分析推断
23011926 GOA
part of chaperonin-containing T-complex IPI
IPI: 通过物理相互作用推断
22133715 GOA
located in microtubule IDA
IDA: 通过直接分析推断
21525035 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCT7 蛋白结构

Cpn60_TCP1

Cpn60_TCP1: TCP-1/cpn60 chaperonin family (32 - 522)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 543 a.a.
蛋白主名 其他名称

T-complex protein 1 subunit eta

CCT-eta

CCT7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CCT7 Q99832 CCT2 Homo sapiens P78371
Anti Tag CoIP
28514442
种属内
CCT7 Q99832 CCT2 Homo sapiens P78371
Anti Tag CoIP
35271311
种属内
CCT7 Q99832 NHLH1 Homo sapiens Q02575
Y2H Prey Pooling
32296183
种属内
CCT7 Q99832 NHLH1 Homo sapiens Q02575
Y2H Array
32296183
种属内
CCT7 Q99832 WBP2 Homo sapiens Q969T9
Y2H Array
32296183
种属内
CCT7 Q99832 WBP2 Homo sapiens Q969T9
Y2H Prey Pooling
32296183
种属内
CCT7 Q99832 ZNRD2 Homo sapiens O60232
Anti Tag CoIP
35271311
种属内
CCT7 Q99832 ZNRD2 Homo sapiens O60232
Y2H Array
31515488
种属内
CCT7 Q99832 ZNRD2 Homo sapiens O60232
Validated Y2H
25416956
种属内
CCT7 Q99832 ZNRD2 Homo sapiens O60232
Y2H Array
25416956
种属内
CCT7 Q99832 ZNRD2 Homo sapiens O60232
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1
Babesiosis

Babesiasis

Infection By Babesia

Piroplasmosis

Human Babesiosis

Babesia Parasite Infection

Piroplasma Infection
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02184 CCT7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CCT7 VGNC VGNC:27000
Mus musculus CCT7 MGD MGI:107184
Rattus norvegicus CCT7 RGD RGD:1306422
Macaca mulatta CCT7 VGNC VGNC:103798
Felis catus CCT7 VGNC VGNC:60581
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