1. Gene
  2. TRIM55 - tripartite motif containing 55 Gene

TRIM55 - tripartite motif containing 55 Gene

中文名称:含三方基序 55

种属: Homo sapiens

同用名: RNF29; muRF2; MURF-2

基因 ID: 84675 | 基因类型: protein coding

关于 TRIM55

Cytogenetic location: 8q13.1 Genomic coordinates (GRCh38): 8:66,113,351-66,175,485 (from NCBI)

This gene has 5 transcripts (splice variants), 272 orthologues and 80 paralogues. Biased expression in heart (RPKM 14.3), liver (RPKM 6.5) and 2 other tissues.

功能概要

由该基因编码的蛋白质包含一个 RING 锌指,这是一种已知参与蛋白质-蛋白质相互作用的基序。这种蛋白质在肌肉肌节组装过程中与微管、肌球蛋白和肌联蛋白短暂结合。它可以充当瞬时适配器并在肌节组装中发挥调节作用。已经描述了编码不同亚型的四种可变剪接的转录物变体。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, Myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

TRIM55 基因产物(4)

mRNA Protein Name
NM_033058.3 NP_149047.2 tripartite motif-containing protein 55 isoform 2
NM_184085.2 NP_908973.1 tripartite motif-containing protein 55 isoform 1
NM_184086.2 NP_908974.1 tripartite motif-containing protein 55 isoform 3
NM_184087.2 NP_908975.1 tripartite motif-containing protein 55 isoform 4
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
22493164 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22493164 GOA
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
37816088 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
37816088 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
37816088 GOA
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
37816088 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TRIM55 蛋白结构

zf-C3HC4_2

zf-C3HC4_2: Zinc finger, C3HC4 type (RING finger) (26 - 81)

zf-B_box

zf-B_box: B-box zinc finger (120 - 155)

  • 0
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  • 500
  • 548 a.a.
蛋白主名 其他名称

tripartite motif-containing protein 55

muscle specific ring finger 2

TRIM55 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TRIM55 Q9BYV6 USP13 Homo sapiens Q92995
Anti Tag CoIP
31391242
种属内
TRIM55 Q9BYV6 USP35 Homo sapiens Q9P2H5
Anti Tag CoIP
31391242
种属内
TRIM55 Q9BYV6 USP13 Homo sapiens Q92995
Y2H Prey Pooling
31391242
种属内
TRIM55 Q9BYV6 AEBP2 Homo sapiens Q6ZN18-2
Y2H Prey Pooling
31391242
种属内
TRIM55 Q9BYV6 acbd4 Homo sapiens EBI-21999915
Y2H Prey Pooling
31391242
种属内
TRIM55 Q9BYV6 TRIM55 Homo sapiens Q9BYV6
Y2H Array
22493164
种属内
TRIM55 Q9BYV6 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
31391242
种属内
TRIM55 Q9BYV6 znf767-5 Homo sapiens EBI-22023041
Y2H Prey Pooling
31391242
种属内
TRIM55 Q9BYV6 SERPINB3 Homo sapiens P29508
Anti Tag CoIP
33961781
种属内
TRIM55 Q9BYV6 TRIM55 Homo sapiens Q9BYV6
Anti Tag CoIP
22493164
种属内
TRIM55 Q9BYV6 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
31391242
种属内
TRIM55 Q9BYV6 MYLK2 Homo sapiens Q9H1R3
Anti Tag CoIP
31391242
种属内
TRIM55 Q9BYV6 ypel3-5 Homo sapiens EBI-22021574
Y2H Prey Pooling
31391242
种属内
TRIM55 Q9BYV6 ACD Homo sapiens Q96AP0
Y2H Prey Pooling
31391242
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hyaline Body Myopathy

Myosin Storage Myopathy

Autosomal Dominant Hyaline Body Myopathy

Myopathy, Myosin Storage

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy Hypertrophic Obstructive

Cardiomyopathy, Hypertrophic, Familial

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis

Noonan Syndrome 8

NS8

Noonan Syndrome, Type 8

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TRIM55 VGNC VGNC:78951
Rattus norvegicus TRIM55 RGD RGD:1306943
Bos taurus TRIM55 VGNC VGNC:36341
Mus musculus TRIM55 MGD MGI:3036269
Felis catus TRIM55 VGNC VGNC:66545
Canis familiaris TRIM55 VGNC VGNC:47827