ARFGAP1 - ADP ribosylation factor GTPase activating protein 1 Gene

中文名称：ADP 核糖基化因子 GTP 酶激活蛋白 1

种属: Homo sapiens

同用名: ARF1GAP; HRIHFB2281

基因 ID: 55738 | 基因类型: protein coding

关于 ARFGAP1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,272,813-63,289,790 (from NCBI)

This gene has 23 transcripts (splice variants), 198 orthologues and 28 paralogues. Ubiquitous expression in spleen (RPKM 11.8), testis (RPKM 11.1) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种 GTPase 激活蛋白，它与高尔基体结合并与 ADP-核糖基化因子 1 相互作用。编码的蛋白质促进 ADP-核糖基化因子 1 结合的 GTP 的水解，并且是解离来自高尔基体衍生的膜和囊泡的外壳蛋白。这些囊泡与靶区室融合需要外壳蛋白的解离。这种蛋白质的活性受磷酸肌苷刺激，受磷脂酰胆碱抑制。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 7 月]

The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

ARFGAP1 基因产物(5)

mRNA	Protein	Name
NM_001281482.2	NP_001268411.1	ADP-ribosylation factor GTPase-activating protein 1 isoform c
NM_001281483.2	NP_001268412.1	ADP-ribosylation factor GTPase-activating protein 1 isoform d
NM_001281484.2	NP_001268413.1	ADP-ribosylation factor GTPase-activating protein 1 isoform e
NM_018209.4	NP_060679.1	ADP-ribosylation factor GTPase-activating protein 1 isoform a
NM_175609.3	NP_783202.1	ADP-ribosylation factor GTPase-activating protein 1 isoform b

ARFGAP1 蛋白结构

ArfGap

0
100
200
300
406 a.a.

蛋白主名

其他名称

ADP-ribosylation factor GTPase-activating protein 1

ARF1-directed GTPase-activating protein

ARFGAP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ARFGAP1	Q8N6T3	FOS	Homo sapiens	Q6FG41	Y2H Prey Pooling	25416956
种属内	ARFGAP1	Q8N6T3	GABARAPL2	Homo sapiens	P60520	Validated Y2H	25416956
种属内	ARFGAP1	Q8N6T3	TRIM23	Homo sapiens	P36406	Validated Y2H	25416956
种属内	ARFGAP1	Q8N6T3	GRN	Homo sapiens	P28799	Y2H Prey Pooling	25416956
种属内	ARFGAP1	Q8N6T3	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Ceroid Lipofuscinosis, Neuronal, 4

Ceroid Lipofuscinosis, Neuronal, Parry Type	Cln4b Disease
Neuronal Ceroid Lipofuscinosis 4b	CLN4B
Autosomal Dominant Neuronal Ceroid Lipofuscinosis 4b	Ceroid Lipofuscinosis, Neuronal, 4b, Autosomal Dominant
Adult Neuronal Ceroid Lipofuscinosis	CLN4
Ceroid Lipofuscinosis, Neuronal, 4 , Autosomal Dominant	Neuronal Ceroid Lipofuscinosis 4
Neuronal Ceroid Lipofuscinosis 4 Parry Type	Adult Neuronal Ceroid Lipofuscinosis 4b
Kuf'S Disease Type B	Kuf'S Disease, Autosomal Dominant
Cln4 Disease	Parry Disease
Ceroid Lipofuscinosis, Neuronal 4	Ceroid Lipofuscinosis, Neuronal, 4b , Autosomal Dominant
Kufs Disease Autosomal Dominant	Neuronal Ceroid Lipofuscinosis Parry Type
Ceroid Lipofuscinosis, Neuronal, 4, Parry Type	Lipofuscinosis, Ceroid, Neuronal, Type 4, Parry Type

Hypotrichosis-Lymphedema-Telangiectasia Syndrome

HLTS	Hypotrichosis Lymphedema Telangiectasia Syndrome
Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome	Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome

Hypersensitivity Reaction Type Iv Disease

Immunoproliferative Disorders

Immunoproliferative Disease

Autoimmune Lymphoproliferative Syndrome

ALPS	Canale-Smith Syndrome
Autoimmune Lymphoproliferative Syndrome, Type Ia	Autoimmune Lymphoproliferative Syndrome, Type Ib
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant	Css
Autoimmune Lymphoproliferative Syndrome, Type 1b	Autoimmune Lymphoproliferative Syndrome, Type 1a
Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant	Fas Deficiency
Autoimmune Lymphoproliferative Syndrome 1a	ALPS1A
Autoimmune Lymphoproliferative Syndrome Type Ia	Autoimmune Lymphoproliferative Syndrome 1b
ALPS1B	Autoimmune Lymphoproliferative Syndrome Type Ib

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-12762	QS11	Inhibitor	99.22%	否
HY-RS00899	ARFGAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	ARFGAP1	VGNC	VGNC:69835
Bos taurus	ARFGAP1	VGNC	VGNC:56176
Felis catus	ARFGAP1	VGNC	VGNC:59866
Mus musculus	ARFGAP1	MGD	MGI:2183559
Canis familiaris	ARFGAP1	VGNC	VGNC:38032
Rattus norvegicus	ARFGAP1	RGD	RGD:708452

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ARFGAP1 - ADP ribosylation factor GTPase activating protein 1 Gene

关于 ARFGAP1

功能概要

ARFGAP1 基因产物(5)

ARFGAP1 蛋白结构

ARFGAP1 蛋白互作信息

关联疾病

直系同源

热门区域

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ARFGAP1 - ADP ribosylation factor GTPase activating protein 1 Gene

关于 ARFGAP1

功能概要

ARFGAP1 基因产物(5)

ARFGAP1 蛋白结构

ARFGAP1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z