HSBP1 - heat shock factor binding protein 1 Gene

中文名称：热休克因子结合蛋白 1

种属: Homo sapiens

同用名: NPC-A-13

关于 HSBP1

功能概要

热休克反应是由细胞暴露于热和化学应激引起的，并且通过激活 HSF (热休克因子) 导致热休克诱导基因的表达升高。热休克因子结合蛋白 1 (HSBP1) 是一种与热休克因子 1 (HSF1) 结合的 76 氨基酸蛋白，HSF1 是参与 HS 反应的转录因子。在 HS 反应期间，HSF1 经历从惰性非 DNA 结合单体到活性功能三聚体的构象转变。 HSBP1 核定位并与 HSF1 的活性三聚体状态相互作用以负向调节 HSF1 DNA 结合活性。 HSBP1 在哺乳动物细胞中的过表达抑制了 HSF1 的反式激活活性。当在秀丽隐杆线虫中过度表达时，HSBP1 对热和化学应激后动物的存活有严重影响，这与 HSBP1 作为热休克反应的负调节剂的作用一致。[RefSeq 提供，2008 年 7 月]

The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the Animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]