2. Gene
  3. SP2 - Sp2 transcription factor Gene

SP2 - Sp2 transcription factor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Sp2 转录因子

种属: Homo sapiens

基因 ID: 6668 | 基因类型: protein coding

关于 SP2

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,896,236-47,931,731 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 4.3), spleen (RPKM 3.4) and 25 other tissues.

功能概要

该基因编码 Sp/XKLF 转录因子的 Sp 亚家族成员。 Sp 家族蛋白是序列特异性 DNA 结合蛋白，其特征在于氨基末端反式激活结构域和三个羧基末端锌指基序。该蛋白质包含蛋白质 Sp 亚家族中最不保守的 DNA 结合域，其 DNA 序列特异性不同于其他 Sp 蛋白质。它主要位于与核基质相关的亚核灶内，可以激活或在某些情况下抑制不同启动子的表达。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the Other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]

SP2 基因产物(1)

mRNA Protein Name
NM_003110.6 NP_003101.3 transcription factor Sp2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
10744779 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
10744779 GOA
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
17827154 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21516116 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10744779 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SP2 蛋白结构

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (542 - 568)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (572 - 594)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 613 a.a.
蛋白主名 其他名称

transcription factor Sp2

SP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SP2 Q02086 MCM7 Homo sapiens P33993
Validated Y2H
25416956
种属内
SP2 Q02086 MCM7 Homo sapiens P33993
Y2H Array
25416956
种属内
SP2 Q02086 FHL2 Homo sapiens Q14192
Validated Y2H
25416956
种属内
SP2 Q02086 BANP Homo sapiens Q8N9N5
Validated Y2H
25416956
种属内
SP2 Q02086 BANP Homo sapiens Q8N9N5
Y2H
21516116
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Basidiobolomycosis

Infection By Basidiobolus

Subcutaneous Mucoromycosis Due To Basidiobolus Ranarum
Dracunculiasis

Guinea Worm Disease

Dracontiasis

Dracunculosis

Infection By Dracunculus Medinensis

Gwd

Guinea Worm Infection

Parasitic Infection Caused By Dracunculus Medinensis

Medina Worm Disease

Medinensis

Medina Worm Infestation

Dracunculus Medinensis Infestation

Guinea Worm Infestation
Large Intestine Adenocarcinoma

Adenocarcinoma Of Large Intestine
Leukodystrophy, Hypomyelinating, 2

Pmld1

Hypomyelinating Leukodystrophy 2

HLD2

Pelizaeus-Merzbacher-Like Disease 1

Pelizaeus-Merzbacher-Like Disease Due To Gjc2 Mutation

Pelizaeus-Merzbacher-Like Disease Type 1

Pelizaeus-Merzbacher-Like Disease, 1

Pelizaeus Merzbacher Like Disease

Pelizaeus-Merzbacher-Like Disease

Pmld - Pelizaeus Merzbacher Like Disease

Pelizaeus-Merzbacher-Like Disease Autosomal Recessive Type 1

Pmldar1

Leukodystrophy, Hypomyelinating, Type 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-155176 SP-2-225 Inhibitor / 否
HY-162258 AChE-IN-57 Inhibitor / 否
HY-N10208 Aspericin C / 否
HY-P5870 KTX-Sp2 Inhibitor / 否
HY-RS13605 SP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-137646 Sp-2-Cl-cAMPS / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SP2 MGD MGI:1926162
Canis familiaris SP2 VGNC VGNC:46686
Felis catus SP2 VGNC VGNC:65586
Macaca mulatta SP2 VGNC VGNC:77845
Rattus norvegicus SP2 RGD RGD:1592078
Bos taurus SP2 VGNC VGNC:35153
Macaca fascicularis SP2 NCBI NCBI:102145464
Others SP2 NCBI
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