INTS6 - integrator complex subunit 6 Gene

中文名称：整合复合物亚基 6

种属: Homo sapiens

同用名: HDB; INT6; DBI-1; DDX26; DICE1; DDX26A; Notchl2

关于 INTS6

功能概要

以保守基序 Asp-Glu-Ala-Asp (DEAD) 为特征的 DEAD 盒蛋白是推定的 RNA 解旋酶。该基因编码的蛋白质是一种死盒蛋白，是与 RNA 聚合酶 II 的 C 末端相互作用的复合物的一部分，并参与 snRNA 的 3' 末端加工。此外，该基因是一个候选抑癌基因，位于杂合性缺失 (LOH) 的关键区域。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2015 年 4 月]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015]