2. Gene
  3. XPO7 - exportin 7 Gene

XPO7 - exportin 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：出口 7

种属: Homo sapiens

同用名: EXP7; RANBP16

基因 ID: 23039 | 基因类型: protein coding

关于 XPO7

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:21,919,662-22,006,585 (from NCBI)

This gene has 9 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 19.6), thyroid (RPKM 15.0) and 25 other tissues.

功能概要

蛋白质和大分子 RNA 通过核孔复合体 (NPC) 的转运是一个能量依赖和受调节的过程。具有核定位信号 (NLS) 的蛋白质的输入是通过输入蛋白-α/β 复合物识别一个或多个碱性氨基酸簇来完成的；参见 MIM 600685 和 MIM 602738。小 GTP 酶 RAN (MIM 601179) 在 NLS 依赖性蛋白质导入中起着关键作用。 RAN 结合蛋白 16 是核转运受体 importin-beta 超家族的成员。[OMIM 提供，2002 年 7 月]

The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic Amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]

XPO7 基因产物(3)

mRNA Protein Name
NM_001100161.2 NP_001093631.1 exportin-7 isoform a
NM_001362802.2 NP_001349731.1 exportin-7 isoform d
NM_015024.5 NP_055839.3 exportin-7 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables nuclear export signal receptor activity IDA
IDA: 通过直接分析推断
11024021 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein export from nucleus IDA
IDA: 通过直接分析推断
11024021 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11071879 GOA
part of nuclear pore IDA
IDA: 通过直接分析推断
11024021 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11071879 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

XPO7 蛋白结构

IBN_N

IBN_N: Importin-beta N-terminal domain (30 - 95)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1087 a.a.
蛋白主名 其他名称

exportin-7

RAN binding protein 16

XPO7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra XPO7 Q9UIA9 RAN Homo sapiens P62826
Y2H Prey Pooling
32296183
Intra XPO7 Q9UIA9 RAN Homo sapiens P62826
Y2H Array
32296183
Intra XPO7 Q9UIA9 USO1 Homo sapiens O60763
Validated Y2H
25416956
Intra XPO7 Q9UIA9 USO1 Homo sapiens O60763
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hemolytic Anemia

Anemia, Hemolytic

Anemia Hemolytic

Anaemia Due To Other Disorders Of Glutathione Metabolism

Chronic Non Spherocytic Anaemia

G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia

Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency

Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia

Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia

Favism Anaemia

Haemolytic Anaemia Due Tog6pd Deficiency

Favism

Pentose Phosphate Pathway Disorder Anaemia

Anaemia Due To Pentose Phosphate Pathway Defect
Arts Syndrome

ARTS

Mrxsarts

Ataxia, Fatal X-Linked, With Deafness And Loss Of Vision

Mrxs18

Lethal Ataxia With Deafness And Optic Atrophy

Fatal X-Linked Ataxia With Deafness And Loss Of Vision

Mental Retardation, X-Linked, Syndromic, Arts Type

Mental Retardation, X-Linked, Syndromic 18

Syndromic X-Linked Mental Retardation 18

Syndromic X-Linked Mental Retardation Arts Type

Lethal Ataxia-Deafness-Optic Atrophy

X-Linked Fatal Ataxia With Deafness And Loss Of Vision

Ataxia-Deafness-Optic Atrophy, Lethal

Lethal Ataxia With Hearing Loss And Optic Atrophy

Art
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15893 XPO7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris XPO7 VGNC VGNC:48464
Mus musculus XPO7 MGD MGI:1929705
Bos taurus XPO7 VGNC VGNC:37001
Felis catus XPO7 VGNC VGNC:67115
Rattus norvegicus XPO7 RGD RGD:1310928
Macaca mulatta XPO7 VGNC VGNC:78946
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