1. Gene
  2. USO1 - USO1 vesicle transport factor Gene

USO1 - USO1 vesicle transport factor Gene

中文名称:USO1 囊泡转运因子

种属: Homo sapiens

同用名: TAP; VDP; P115

基因 ID: 8615 | 基因类型: protein coding

关于 USO1

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:75,724,577-75,814,286 (from NCBI)

This gene has 4 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in thyroid (RPKM 38.1), testis (RPKM 30.9) and 25 other tissues.

功能概要

由该基因编码的蛋白质是一种外周膜蛋白,在间期细胞质和高尔基体之间循环。它受磷酸化调节:去磷酸化的蛋白质与高尔基体膜结合并在磷酸化后从膜上解离。 Ras 相关蛋白 1 在从内质网出芽期间募集该蛋白来包裹蛋白复合物 II (COPII) 囊泡,在那里它与一组 COPII 囊泡相关 SNARE 相互作用,形成顺式-SNARE 复合物,促进靶向高尔基体.可变剪接导致多个转录本变体。[RefSeq 提供,2014 年 2 月]

The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

USO1 基因产物(2)

mRNA Protein Name
NM_001290049.2 NP_001276978.1 general vesicular transport factor p115 isoform 1
NM_003715.4 NP_003706.2 general vesicular transport factor p115 isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

USO1 蛋白结构

Uso1_p115_head

Uso1_p115_head: Uso1 / p115 like vesicle tethering protein, head region (329 - 613)

Uso1_p115_C

Uso1_p115_C: Uso1 / p115 like vesicle tethering protein, C terminal region (812 - 937)

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  • 947 a.a.
蛋白主名 其他名称

general vesicular transport factor p115

USO1 vesicle docking protein homolog

USO1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra USO1 O60763 XPO7 Homo sapiens Q9UIA9
Y2H Array
25416956
Intra USO1 O60763 DUSP12 Homo sapiens Q9UNI6
Y2H Array
25416956
Intra USO1 O60763 DUSP12 Homo sapiens Q9UNI6
Validated Y2H
25416956
Intra USO1 O60763 PHYKPL Homo sapiens Q8IUZ5
Y2H Prey Pooling
25416956
Intra USO1 O60763 AKAP9 Homo sapiens Q99996-2
Y2H Array
25416956
Intra USO1 O60763 AKAP9 Homo sapiens Q99996-2
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Canis familiaris USO1 VGNC VGNC:48176
Bos taurus USO1 VGNC VGNC:36708
Macaca mulatta USO1 VGNC VGNC:79896
Rattus norvegicus USO1 RGD RGD:621604
Felis catus USO1 VGNC VGNC:66863
Mus musculus USO1 MGD MGI:1929095