DUSP12 - dual specificity phosphatase 12 Gene

中文名称：双特异性磷酸酶 12

种属: Homo sapiens

同用名: YVH1; DUSP1

关于 DUSP12

功能概要

该基因编码的蛋白质是双特异性蛋白磷酸酶亚家族的成员。这些磷酸酶通过使磷酸丝氨酸/苏氨酸和磷酸酪氨酸残基去磷酸化来灭活它们的靶激酶。它们负向调节与细胞增殖和分化相关的丝裂原活化蛋白 (MAP) 激酶超家族成员 (MAPK/ERK、SAPK/JNK、p38) 。双特异性磷酸酶家族的不同成员对各种 MAP 激酶表现出不同的底物特异性、不同的组织分布和亚细胞定位，以及细胞外刺激表达的不同诱导模式。该基因产物是酿酒酵母 YVH1 蛋白酪氨酸磷酸酶的人类直系同源物。它主要位于细胞核中，并且新颖之处在于它包含锌指结构域并受其调节。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the dual specificity protein Phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine Phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]