2. Gene
  3. TNPO1 - transportin 1 Gene

TNPO1 - transportin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：运输 1

种属: Homo sapiens

同用名: MIP; TRN; IPO2; MIP1; KPNB2

基因 ID: 3842 | 基因类型: protein coding

关于 TNPO1

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:72,816,661-72,914,388 (from NCBI)

This gene has 19 transcripts (splice variants), 215 orthologues and 5 paralogues. Ubiquitous expression in thyroid (RPKM 18.9), testis (RPKM 17.9) and 25 other tissues.

功能概要

该基因编码 karyopherin 受体复合物的 β 亚基，该复合物与核定位信号相互作用，将核蛋白靶向细胞核。核转运蛋白受体复合物是识别核定位信号的α亚基和将复合物停靠在核孔蛋白处的β亚基的异二聚体。该基因的交替剪接导致编码不同蛋白质的几种转录变体。[RefSeq 提供，2018 年 6 月]

This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in several transcript variants encoding different proteins. [provided by RefSeq, Jun 2018]

TNPO1 基因产物(7)

mRNA Protein Name
NM_001364292.3 NP_001351221.1 transportin-1 isoform 2
NM_001364293.3 NP_001351222.1 transportin-1 isoform 2
NM_001364294.3 NP_001351223.1 transportin-1 isoform 3
NM_001364295.3 NP_001351224.1 transportin-1 isoform 4
NM_001364296.2 NP_001351225.1 transportin-1 isoform 5
NM_002270.4 NP_002261.3 transportin-1 isoform 1
NM_153188.4 NP_694858.1 transportin-1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10353245 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein import into nucleus IDA
IDA: 通过直接分析推断
9144189 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TNPO1 蛋白结构

IBN_N

IBN_N: Importin-beta N-terminal domain (42 - 108)

HEAT_EZ

HEAT_EZ: HEAT-like repeat (419 - 472)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 898 a.a.
蛋白主名 其他名称

transportin-1

M9 region interaction protein

TNPO1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TNPO1 Q92973 RAN Homo sapiens P62826
X-Ray Diffraction
10353245
Intra TNPO1 Q92973 HNRNPA1 Homo sapiens P09651-2
Pull Down
17435768
Intra TNPO1 Q92973 HNRNPA1 Homo sapiens P09651-2
ITC
17435768
Intra TNPO1 Q92973 HNRNPM Homo sapiens P52272
Pull Down
17435768
Intra TNPO1 Q92973 HNRNPM Homo sapiens P52272
ITC
17435768
Intra TNPO1 Q92973 HNRNPM Homo sapiens P52272
X-Ray Diffraction
17435768
Intra TNPO1 Q92973 HNRNPA0 Homo sapiens Q13151
Anti Tag CoIP
35271311
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Retinitis Pigmentosa 2

RP2

X-Linked Retinitis Pigmentosa 2

Xlrp2

Xlrp-2

Retinitis Pigmentosa-2

Retinitis Pigmentosa, Type 2
Multisystem Proteinopathy
Meningoencephalitis

Acquired Toxoplasmal Meningoencephalitis

Meningoencephalitis Due To Acquired Toxoplasmosis

Meningoencephalitis Due To Toxoplasmosis

Toxoplasma Meningoencephalitis
Epithelial-Stromal Tgfbi Dystrophy
Lattice Corneal Dystrophy

Familial Amyloid Neuropathy, Finnish Type

Familial Amyloid Polyneuropathy, Type V
Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14859 TNPO1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TNPO1 RGD RGD:1308372
Felis catus TNPO1 VGNC VGNC:67980
Bos taurus TNPO1 VGNC VGNC:36199
Canis familiaris TNPO1 VGNC VGNC:47694
Macaca mulatta TNPO1 VGNC VGNC:79961
Mus musculus TNPO1 MGD MGI:2681523
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