1. Membrane Transporter/Ion Channel
  2. CRM1
  3. CW0134

CW0134 (Compound 12) 是 exportin1 (XPO1) 的调节剂。CW0134 破坏染色质结合,抑制 NFAT 转录因子和 T 细胞的活化。

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CW0134 Chemical Structure

CW0134 Chemical Structure

CAS No. : 1076235-18-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CW0134 (Compound 12) is a modulator for exportin1 (XPO1) ,which disrupts the chromatin binding, inhibits NFAT transcription factors and activation of T cells[1].

体外研究
(In Vitro)

CW0134 (10 nM-10 μM) 抑制 Jurkat 细胞中 IL-2 的表达 (6 h) 和 Jurkat 的细胞活力 (24 h)[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Jurkat
Concentration: 10 nM-10 μM
Incubation Time: 24 h
Result: Inhibited cell viability of Jurkats.
分子量

305.64

Formula

C11H7ClF3N3O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
CW0134
目录号:
HY-161391
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