ILF3 - interleukin enhancer binding factor 3 Gene

中文名称：白细胞介素增强子结合因子 3

种属: Homo sapiens

同用名: CBTF; DRBF; MMP4; MPP4; NF90; NFAR; NF110; NF90a; NF90b; NF90c; NFAR2; TCP80; DRBP76; NF110b; NFAR-1; NFAR-2; NFAR90; TCP110; MPP4110; NF90ctv; NFAR110; MPHOSPH4; NF-AT-90

关于 ILF3

功能概要

该基因编码一种双链 RNA (dsRNA) 结合蛋白，该蛋白与其他蛋白质、dsRNA、小的非编码 RNA 和 mRNA 复合，以调节基因表达并稳定 mRNA。这种蛋白质 (NF90、ILF3) 与 T 细胞表达白细胞介素 2 所需的 45 kDa 转录因子 (NF45、ILF2) 形成异二聚体。已证明该复合物会影响核 mRNA 向细胞质的重新分布。 NF45 或 NF90 蛋白的敲低可能通过抑制 mRNA 稳定来延迟细胞生长。相比之下，该基因的一种同种型 (NF110) 主要局限于细胞核，当其水平降低时，对细胞生长的影响很小。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2014 年 12 月]

This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with Other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]