PINX1 - PIN2 (TERF1) interacting telomerase inhibitor 1 Gene

中文名称：PIN2 (TERF1) 相互作用的端粒酶抑制因子 1

种属: Homo sapiens

同用名: Gno1; LPTL; LPTS; Pxr1

基因 ID: 54984 | 基因类型: protein coding

关于 PINX1

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:10,764,961-10,839,875 (from NCBI)

This gene has 8 transcripts (splice variants), 190 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 5.1), appendix (RPKM 4.5) and 25 other tissues.

功能概要

启用端粒酶 RNA 结合活性和端粒酶抑制剂活性。参与多个过程，包括 DNA 生物合成过程的负调控；蛋白质定位到核仁的正向调节；和蛋白质定位到细胞器。通过端粒酶作用于端粒维护的上游或内部。位于多个细胞成分中，包括染色体区域；核腔;和主轴。 [由基因组资源联盟提供，2022 年 4 月]

Enables Telomerase RNA binding activity and Telomerase Inhibitor activity. Involved in several processes, including negative regulation of DNA biosynthetic process; positive regulation of protein localization to nucleolus; and protein localization to organelle. Acts upstream of or within telomere maintenance via Telomerase. Located in several cellular components, including chromosomal region; nuclear lumen; and spindle. [provided by Alliance of Genome Resources, Apr 2022]

PINX1 基因产物(2)

mRNA	Protein	Name
NM_001284356.2	NP_001271285.1	PIN2/TERF1-interacting telomerase inhibitor 1 isoform 2
NM_017884.6	NP_060354.4	PIN2/TERF1-interacting telomerase inhibitor 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11701125	GOA
enables protein-containing complex binding	IPI IPI: 通过物理相互作用推断	18202258	GOA
enables telomerase RNA binding	IDA IDA: 通过直接分析推断	15381700	GOA
enables telomerase inhibitor activity	IDA IDA: 通过直接分析推断	11701125	GOA
enables telomerase inhibitor activity	IMP IMP: 通过突变表型推断	21119197	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mitotic metaphase chromosome alignment	IMP IMP: 通过突变表型推断	19393617	GOA
involved in negative regulation of G2/M transition of mitotic cell cycle	IDA IDA: 通过直接分析推断	11701125	GOA
involved in negative regulation of protein ubiquitination	IMP IMP: 通过突变表型推断	24415760	GOA
involved in negative regulation of telomere maintenance via telomerase	IDA IDA: 通过直接分析推断	11701125	GOA
involved in negative regulation of telomere maintenance via telomerase	IMP IMP: 通过突变表型推断	21119197	GOA
involved in positive regulation of protein localization to nucleolus	IDA IDA: 通过直接分析推断	19265708	GOA
involved in positive regulation of telomeric DNA binding	IDA IDA: 通过直接分析推断	19265708	GOA
involved in protein localization to chromosome, telomeric region	IMP IMP: 通过突变表型推断	22749911	GOA
involved in protein localization to nucleolus	IDA IDA: 通过直接分析推断	24415760	GOA
involved in regulation of protein stability	IMP IMP: 通过突变表型推断	24415760	GOA
acts upstream of or within telomere maintenance via telomerase	IDA IDA: 通过直接分析推断	11701125	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromosome, telomeric region	IDA IDA: 通过直接分析推断	11701125	GOA
located in kinetochore	IDA IDA: 通过直接分析推断	19393617	GOA
located in nuclear chromosome	IDA IDA: 通过直接分析推断	19393617	GOA
located in nucleolus	IDA IDA: 通过直接分析推断	11701125	GOA
located in spindle	IDA IDA: 通过直接分析推断	19393617	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PINX1 蛋白结构

G-patch

0
100
200
300
328 a.a.

蛋白主名

其他名称

PIN2/TERF1-interacting telomerase inhibitor 1

67-11-3 protein

PINX1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PINX1	Q96BK5	TERT	Homo sapiens	O14746	Anti Bait CoIP	28255170
Intra	PINX1	Q96BK5	TERT	Homo sapiens	O14746	Anti Tag CoIP	28255170
Intra	PINX1	Q96BK5	UBL5	Homo sapiens	Q9BZL1	Validated Y2H	32296183
Intra	PINX1	Q96BK5	TERF1	Homo sapiens	P54274	Anti Tag CoIP	33961781
Intra	PINX1	Q96BK5	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	PINX1	Q96BK5	TERF1	Homo sapiens	P54274	CoIP	11701125
Intra	PINX1	Q96BK5	TERF1	Homo sapiens	P54274	IF	11701125
Intra	PINX1	Q96BK5	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	PINX1	Q96BK5	TLK1	Homo sapiens	Q9UKI8	Validated Y2H	32296183
Intra	PINX1	Q96BK5	NPM1	Homo sapiens	P06748	Pull Down	28255170
Intra	PINX1	Q96BK5	NPM1	Homo sapiens	P06748	Affinity Chrom	28255170
Intra	PINX1	Q96BK5	NPM1	Homo sapiens	P06748	IF	28255170
Intra	PINX1	Q96BK5	NPM1	Homo sapiens	P06748	Anti Bait CoIP	28255170
Intra	PINX1	Q96BK5	NPM1	Homo sapiens	P06748	Anti Tag CoIP	28255170
Intra	PINX1	Q96BK5	NPM1	Homo sapiens	P06748	Anti Bait CoIP	17353931

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Inflammatory Bowel Disease 22

IBD22

Thrombophlebitis Migrans

Ulcerative Stomatitis

Stomatitis Ulcerative	Aphthous Stomatitis
Minor Oral Aphthous Ulceration

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10560	PINX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	PINX1	VGNC	VGNC:79362
Mus musculus	PINX1	MGD	MGI:1919650
Rattus norvegicus	PINX1	RGD	RGD:1566025
Bos taurus	PINX1	VGNC	VGNC:32905
Canis familiaris	PINX1	VGNC	VGNC:44569

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PINX1 - PIN2 (TERF1) interacting telomerase inhibitor 1 Gene

关于 PINX1

功能概要

PINX1 基因产物(2)

PINX1 蛋白结构

PINX1 蛋白互作信息

关联疾病

直系同源

热门区域

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PINX1 - PIN2 (TERF1) interacting telomerase inhibitor 1 Gene

关于 PINX1

功能概要

PINX1 基因产物(2)

PINX1 蛋白结构

PINX1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z