1. Gene
  2. ZNF143 - zinc finger protein 143 Gene

ZNF143 - zinc finger protein 143 Gene

中文名称:锌指蛋白 143

种属: Homo sapiens

同用名: SBF; STAF; pHZ-1

基因 ID: 7702 | 基因类型: protein coding

关于 ZNF143

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:9,461,012-9,528,524 (from NCBI)

This gene has 18 transcripts (splice variants), 220 orthologues and 36 paralogues. Ubiquitous expression in testis (RPKM 5.8), lymph node (RPKM 4.3) and 25 other tissues.

功能概要

启用 DNA 结合转录激活因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。参与 RNA 聚合酶 II 对 snRNA 转录的正调控。预测位于核质中。 [由基因组资源联盟提供,2022 年 4 月]

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of snRNA transcription by RNA polymerase II. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZNF143 基因产物(3)

mRNA Protein Name
NM_001282656.2 NP_001269585.1 zinc finger protein 143 isoform 2
NM_001282657.2 NP_001269586.1 zinc finger protein 143 isoform 3
NM_003442.6 NP_003433.3 zinc finger protein 143 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
10893243 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
10893243 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17938208 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of snRNA transcription by RNA polymerase II EXP
EXP: 通过实验结果推断
9009278 GOA
involved in positive regulation of transcription by RNA polymerase II EXP
EXP: 通过实验结果推断
9009278 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10893243 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ZNF143 蛋白结构

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (253 - 280)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (284 - 310)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (313 - 340)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (346 - 369)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (373 - 399)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (417 - 440)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 638 a.a.
蛋白主名 其他名称

zinc finger protein 143

SPH-binding factor

ZNF143 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZNF143 P52747 IQUB Homo sapiens Q8NA54
Validated Y2H
32296183
种属内
ZNF143 P52747 NUDT22 Homo sapiens Q9BRQ3
Validated Y2H
32296183
种属内
ZNF143 P52747 YJU2 Homo sapiens Q9BW85
Validated Y2H
32296183
种属内
ZNF143 P52747 ZNF512B Homo sapiens Q96KM6
Validated Y2H
32296183
种属内
ZNF143 P52747 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
种属内
ZNF143 P52747 ZNF438 Homo sapiens Q7Z4V0
Validated Y2H
32296183
种属内
ZNF143 P52747 ZNF438 Homo sapiens Q7Z4V0
Y2H Prey Pooling
32296183
种属内
ZNF143 P52747 TCAF1 Homo sapiens Q9Y4C2-2
Validated Y2H
32296183
种属内
ZNF143 P52747 SPANXN3 Homo sapiens Q5MJ09
Validated Y2H
32296183
种属内
ZNF143 P52747 LIN54 Homo sapiens Q6MZP7
Validated Y2H
32296183
种属内
ZNF143 P52747 IL16 Homo sapiens Q14005-2
Validated Y2H
32296183
种属内
ZNF143 P52747 TAB2 Homo sapiens Q9NYJ8
Validated Y2H
32296183
种属内
ZNF143 P52747 EXOSC1 Homo sapiens Q9Y3B2
Validated Y2H
32296183
种属内
ZNF143 P52747 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
32296183
种属内
ZNF143 P52747 FHL2 Homo sapiens Q14192
Validated Y2H
32296183
种属内
ZNF143 P52747 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
种属内
ZNF143 P52747 EAF1 Homo sapiens Q96JC9
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Disorders Of Intracellular Cobalamin Metabolism
Spherocytosis, Type 5

Hereditary Spherocytosis Type 5

SPH5

Hs5

Spherocytosis, Hereditary, 5

Hereditary Spherocytosis 5

Spherocytosis 5

Spherocytosis, Hereditary, Type 5

Basilar Artery Insufficiency

Basilar Artery Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ZNF143 VGNC VGNC:81612
Rattus norvegicus ZNF143 RGD RGD:1305662
Mus musculus ZNF143 MGD MGI:1277969
Canis familiaris ZNF143 VGNC VGNC:48661
Felis catus ZNF143 VGNC VGNC:67268
Bos taurus ZNF143 VGNC VGNC:58348