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  4. YPC-22026

YPC-22026 是一种锌指蛋白 143 (ZNF143) 抑制剂，IC50 值为 9.0 μM。YPC-22026 是一种有效的肿瘤消退诱导剂。YPC-22026 表现出抗肿瘤活性。

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YPC-22026 Chemical Structure

YPC-22026 Chemical Structure

CAS No. : 1964457-41-7

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规格 价格 是否有货 数量
1 mg ￥3955
1 - 2 周
5 mg 现货 1 - 2 周
10 mg   询价  
50 mg   询价  

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YPC-22026 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YPC-22026 is a zinc-finger protein 143 (ZNF143) inhibitor with an IC50 value of 9.0 μM. YPC-22026 is a potent tumor regression inducer. YPC-22026 exhibits anti‐tumor activities[1].

体外研究
(In Vitro)

YPC-22026 (96 小时) 对 HCT116 和 PC-3 具有细胞毒性，IC50 值分别为 0.33 μM 和 0.66 μM[1]。
YPC-22026 (3 μM；24 小时) 诱导 G2/M 停滞并降低 ZNF143 与 STAF 结合位点的结合[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

YPC-22026 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HCT116 cells
Concentration: 3 μM
Incubation Time: 24 h
Result: Induced G2/M arrest.
体内研究
(In Vivo)

YPC-22026（50-100 mg/kg；腹腔注射；第 1、2、3、8、9、12 和 16 天）显著抑制 HCT116 异种移植模型中肿瘤的生长[1]。
在 PC-3 异种移植模型中，YPC-22026（75 mg/kg；腹腔注射）显著降低所有 ZNF143 靶基因、RAD51、PLK1 和 Survivin 的肿瘤内表达水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six‐week‐old male BALB/c nude mice injected with HCT116 cells[1]
Dosage: 50 mg/kg and 100 mg/kg
Administration: i.p; on days 1, 2, 3, 8, 9, 12, and 16 (50 mg/kg ); on days 1, 2, 3, 12, and 16 (100 mg/kg)
Result: Significantly inhibited the growth of tumors.
分子量

331.25

Formula

C16H8F3N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YPC-22026 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YPC-220261964457-41-7YPC22026YPC 22026Otherstumor regression inducerZNF143 inhibitoranti‐tumor activitiesRAD51PLK1SurvivinInhibitorinhibitorinhibit

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目录号：
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