1. Gene
  2. LIN54 - lin-54 DREAM MuvB core complex component Gene

LIN54 - lin-54 DREAM MuvB core complex component Gene

中文名称:lin-54 DREAM MuvB 核心复杂组件

种属: Homo sapiens

同用名: TCX1; JC8.6; CXCDC1; MIP120

基因 ID: 132660 | 基因类型: protein coding

关于 LIN54

Cytogenetic location: 4q21.22 Genomic coordinates (GRCh38): 4:82,924,603-83,012,941 (from NCBI)

This gene has 10 transcripts (splice variants), 206 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 5.1), esophagus (RPKM 4.0) and 25 other tissues.

功能概要

LIN54 是 LIN 或 DREAM 复合体的一个组成部分,它是细胞周期基因的重要调节因子 (Schmit 等人,2009 [PubMed 19725879]) 。[OMIM 提供,2010 年 12 月]

LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]).[supplied by OMIM, Dec 2010]

LIN54 基因产物(5)

mRNA Protein Name
NM_001115007.3 NP_001108479.1 protein lin-54 homolog isoform b
NM_001115008.3 NP_001108480.1 protein lin-54 homolog isoform b
NM_001288996.2 NP_001275925.1 protein lin-54 homolog isoform c
NM_001288997.1 NP_001275926.1 protein lin-54 homolog isoform b
NM_194282.4 NP_919258.2 protein lin-54 homolog isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables minor groove of adenine-thymine-rich DNA binding IDA
IDA: 通过直接分析推断
27465258 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17531812 GOA
enables transcription regulatory region nucleic acid binding IDA
IDA: 通过直接分析推断
27465258 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within nucleosome organization IDA
IDA: 通过直接分析推断
27465258 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription repressor complex IDA
IDA: 通过直接分析推断
27465258 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

LIN54 蛋白结构

TCR

TCR: Tesmin/TSO1-like CXC domain, cysteine-rich domain (522 - 560)

TCR

TCR: Tesmin/TSO1-like CXC domain, cysteine-rich domain (594 - 634)

  • 0
  • 200
  • 400
  • 600
  • 749 a.a.
蛋白主名 其他名称

protein lin-54 homolog

CXC domain-containing protein 1

LIN54 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LIN54 Q6MZP7 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra LIN54 Q6MZP7 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
Intra LIN54 Q6MZP7 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
Intra LIN54 Q6MZP7 MYBL2 Homo sapiens P10244
Anti Tag CoIP
19725879
Intra LIN54 Q6MZP7 MYBL2 Homo sapiens P10244
Anti Bait CoIP
17531812
Intra LIN54 Q6MZP7 SF3A2 Homo sapiens Q15428
Y2H Array
32296183
Intra LIN54 Q6MZP7 SF3A2 Homo sapiens Q15428
Y2H Prey Pooling
32296183
Intra LIN54 Q6MZP7 ZNF143 Homo sapiens P52747
Y2H Prey Pooling
32296183
Intra LIN54 Q6MZP7 ZNF143 Homo sapiens P52747
Y2H Array
32296183
Intra LIN54 Q6MZP7 SP3 Homo sapiens Q02447
Y2H Prey Pooling
32296183
Intra LIN54 Q6MZP7 SP3 Homo sapiens Q02447
Y2H Array
32296183
Intra LIN54 Q6MZP7 ZNF76 Homo sapiens P36508
Y2H Prey Pooling
32296183
Intra LIN54 Q6MZP7 ZNF76 Homo sapiens P36508
Y2H Array
32296183
Intra LIN54 Q6MZP7 RBL2 Homo sapiens Q08999
Anti Tag CoIP
19725879
Intra LIN54 Q6MZP7 RBL2 Homo sapiens Q08999
Anti Bait CoIP
17531812
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spondyloarthropathy 1

Ankylosing Spondylitis

Spondyloarthropathy, Susceptibility To, 1

SPDA1

Marie-Strumpell Spondylitis

Bechterew Syndrome

Spa

Spondylarthritis Ankylopoietica

Reiter Syndrome

Ankylosing Spondylitis, Susceptibility To

Bekhterev Syndrome

Bekhterev'S Disease

Marie-Strumpell Disease

Axial Spondylarthritis

Bechterew Disease

Marie-Struempell Disease

Spondylitis Ankylopoietica

Spondyloarthritis

Spondyloarthritis Ankylopoietica

Spas

Ankylosing Spondylarthritis

Psoriatic Arthritis

Reactive Arthritis

Rheumatoid Spondylitis

Spondylitis Ankylosans

Spondylitis Ankylosing

Spondylitis, Ankylosing

Spondylarthropathies

Arthritis, Psoriatic

Arthritis, Reactive

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus LIN54 MGD MGI:2140902
Canis familiaris LIN54 VGNC VGNC:42685
Bos taurus LIN54 VGNC VGNC:30894
Rattus norvegicus LIN54 RGD RGD:1311361
Felis catus LIN54 VGNC VGNC:63232
Macaca mulatta LIN54 VGNC VGNC:74123