2. Gene
  3. MYBL2 - MYB proto-oncogene like 2 Gene

MYBL2 - MYB proto-oncogene like 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MYB 原癌基因样 2

种属: Homo sapiens

同用名: BMYB; B-MYB

基因 ID: 4605 | 基因类型: protein coding

关于 MYBL2

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:43,667,114-43,716,482 (from NCBI)

This gene has 2 transcripts (splice variants), 264 orthologues and 6 paralogues. Biased expression in bone marrow (RPKM 29.8), lymph node (RPKM 25.5) and 11 other tissues.

功能概要

由该基因编码的蛋白质是转录因子基因 MYB 家族的成员，是一种参与细胞周期进程的核蛋白。编码的蛋白质在细胞周期的 S 期被细胞周期蛋白 A/细胞周期蛋白依赖性激酶 2 磷酸化，并具有激活和抑制活性。它已被证明可以激活细胞分裂周期 2、细胞周期蛋白 D1 和胰岛素样生长因子结合蛋白 5 基因。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2013 年 7 月]

The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

MYBL2 基因产物(2)

mRNA Protein Name
NM_001278610.2 NP_001265539.1 myb-related protein B isoform 2
NM_002466.4 NP_002457.1 myb-related protein B isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
10770937 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
10770937 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17159899 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10770937 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MYBL2 蛋白结构

Myb_DNA-bind_6

Myb_DNA-bind_6: Myb-like DNA-binding domain (34 - 94)

Myb_DNA-binding

Myb_DNA-binding: Myb-like DNA-binding domain (136 - 178)

Cmyb_C

Cmyb_C: C-myb, C-terminal (451 - 605)

  • 0
  • 200
  • 400
  • 600
  • 700 a.a.
蛋白主名 其他名称

myb-related protein B

myb-like protein 2

MYBL2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MYBL2 P10244 LIN9 Homo sapiens Q5TKA1
Anti Tag CoIP
17159899
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Paraneoplastic Cerebellar Degeneration

Pcd

Paraneoplastic Cerebellar Ataxia

Rapidely Progressive Cerebellar Syndrome

Subacute Cerebellar Degeneration
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Advanced Sleep Phase Syndrome, Familial, 3

Advanced Sleep Phase Syndrome 3

FASPS3

Familial Advanced Sleep Phase Syndrome 3

Sleep Phase Syndrome, Advanced, Familial, Type 3
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08872 MYBL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MYBL2 VGNC VGNC:68372
Rattus norvegicus MYBL2 RGD RGD:1308474
Bos taurus MYBL2 VGNC VGNC:31779
Mus musculus MYBL2 MGD MGI:101785
Macaca mulatta MYBL2 VGNC VGNC:75092
Canis familiaris MYBL2 VGNC VGNC:43521
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