2. Gene
  3. CDX4 - caudal type homeobox 4 Gene

CDX4 - caudal type homeobox 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：尾型同源框 4

种属: Homo sapiens

基因 ID: 1046 | 基因类型: protein coding

关于 CDX4

Cytogenetic location: Xq13.2 Genomic coordinates (GRCh38): X:73,447,053-73,455,171 (from NCBI)

This gene has 1 transcript (splice variant), 96 orthologues and 2 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码含有转录因子的同源框小亚科的成员。编码的蛋白质可能在前后模式和造血过程中调节同源盒基因表达。[RefSeq 提供，2012 年 8 月]

This gene encodes a member of a small subfamily of homeobox containing transcription factors. The encoded protein may regulate homeobox gene expression during anteroposterior patterning and hematopoiesis. [provided by RefSeq, Aug 2012]

CDX4 基因产物(1)

mRNA Protein Name
NM_005193.2 NP_005184.1 homeobox protein CDX-4
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
21471217 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
21471217 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
21471217 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24722188 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
21471217 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
21471217 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDX4 蛋白结构

Caudal_act

Caudal_act: Caudal like protein activation region (13 - 171)

Homeobox

Homeobox: Homeobox domain (175 - 230)

  • 0
  • 100
  • 200
  • 284 a.a.
蛋白主名 其他名称

homeobox protein CDX-4

caudal type homeobox transcription factor 4

CDX4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CDX4 O14627 PRKAB2 Homo sapiens O43741
Y2H Array
25416956
Intra CDX4 O14627 PRKAB2 Homo sapiens O43741
Y2H Array
31515488
Intra CDX4 O14627 PRKAB2 Homo sapiens O43741
Validated Y2H
25416956
Intra CDX4 O14627 PRKAA2 Homo sapiens P54646
Validated Y2H
32296183
Intra CDX4 O14627 CKS1B Homo sapiens P61024
Validated Y2H
25416956
Intra CDX4 O14627 CKS1B Homo sapiens P61024
Y2H Prey Pooling
25416956
Intra CDX4 O14627 LMO2 Homo sapiens P25791
Y2H Prey Pooling
25416956
Intra CDX4 O14627 LMO2 Homo sapiens P25791
Validated Y2H
25416956
Intra CDX4 O14627 LMO2 Homo sapiens P25791
Y2H Array
25416956
Intra CDX4 O14627 LMO1 Homo sapiens P25800
Y2H Prey Pooling
25416956
Intra CDX4 O14627 LMO1 Homo sapiens P25800
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Renpenning Syndrome 1

Renpenning Syndrome

Golabi-Ito-Hall Syndrome

Mrxs3

Mrxs8

X-Linked Intellectual Disability Due To Pqbp1 Mutations

RENS1

Sutherland-Haan X-Linked Mental Retardation Syndrome

Shs

Mrx55

X-Linked Intellectual Disability, Renpenning Type

Sutherland-Haan Syndrome

Mental Retardation, X-Linked, Renpenning Type

Mental Retardation, X-Linked, With Spastic Diplegia

Mental Retardation, X-Linked, Syndromic 3

Mental Retardation, X-Linked, Syndromic 8

Mental Retardation, X-Linked 55

Syndromic X-Linked Mental Retardation 8

X-Linked Mental Retardation Renpenning Type

X-Linked Mental Retardation With Spastic Diplegia

Sutherland-Haan X-Linked Intellectual Disability Syndrome

X-Linked Intellectual Disability With Spastic Diplegia

Hamel Cerebropalatocardiac Syndrome

Porteous Syndrome

X-Linked Intellectual Deficit Due To Pqbp1 Mutations

X-Linked Intellectual Deficit, Renpenning Type

X-Linked Intellectual Disability, Sutherland-Haan Type

Hamel Cerebro-Palato-Cardiac Syndrome

Renpenning Syndrome, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02431 CDX4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CDX4 VGNC VGNC:27159
Mus musculus CDX4 MGD MGI:88362
Macaca mulatta CDX4 VGNC VGNC:70997
Canis familiaris CDX4 VGNC VGNC:39086
Rattus norvegicus CDX4 RGD RGD:1561529
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