2. Gene
  3. ZNF219 - zinc finger protein 219 Gene

ZNF219 - zinc finger protein 219 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：锌指蛋白 219

种属: Homo sapiens

同用名: ZFP219

基因 ID: 51222 | 基因类型: protein coding

关于 ZNF219

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,090,077-21,104,722 (from NCBI)

This gene has 13 transcripts (splice variants), 158 orthologues and 14 paralogues. Ubiquitous expression in fat (RPKM 12.4), colon (RPKM 6.8) and 22 other tissues.

功能概要

该基因是类 Kruppel 锌指基因家族的成员。编码的蛋白质作为高迁移率族核小体结合域 1 蛋白的转录抑制因子发挥作用，该蛋白与转录活性染色质相关。[RefSeq 提供，2017 年 4 月]

This gene is a member of the Kruppel-like zinc finger gene family. The encoded protein functions as a transcriptional repressor of the high mobility group nucleosome binding domain 1 protein, which is associated with transcriptionally active chromatin. [provided by RefSeq, Apr 2017]

ZNF219 基因产物(3)

mRNA Protein Name
NM_001101672.2 NP_001095142.1 zinc finger protein 219
NM_001102454.2 NP_001095924.1 zinc finger protein 219
NM_016423.3 NP_057507.2 zinc finger protein 219
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
14621294 GOA
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
14621294 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
14621294 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
14621294 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19549071 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
14621294 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
14621294 GOA
involved in regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
19549071 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
10819330 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZNF219 蛋白结构

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (57 - 79)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (85 - 107)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (163 - 186)

zf-H2C2_5

zf-H2C2_5: C2H2-type zinc-finger domain (190 - 213)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (274 - 296)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (302 - 324)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (512 - 535)

zf-H2C2_5

zf-H2C2_5: C2H2-type zinc-finger domain (646 - 669)

  • 0
  • 200
  • 400
  • 600
  • 722 a.a.
蛋白主名 其他名称

zinc finger protein 219

ZNF219 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ZNF219 Q9P2Y4 DR1 Homo sapiens Q01658
Validated Y2H
32814053
Intra ZNF219 Q9P2Y4 DR1 Homo sapiens Q01658
Y2H Pooling
32814053
Intra ZNF219 Q9P2Y4 DR1 Homo sapiens Q01658
Y2H Array
32814053
Intra ZNF219 Q9P2Y4 LMO1 Homo sapiens P25800
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Frontonasal Dysplasia 1

Frontorhiny

Frontonasal Dysplasia

Fnd

Frontonasal Malformation

Fnm

Median Facial Cleft Syndrome

Midline Facial Cleft

FND1

Median Cleft Face Syndrome

Median Cleft Syndrome

Frontonasal Dysplasia Sequence

Median Facial Cleft

Tessier Number 0-14 And 30 Facial Cleft

Alx3-Related Frontonasal Dysplasia

Frontonasal Dysplasia Type 1

Isolated Median Cleft Face Syndrome

Doid:0081044

Doid:0081045

Dysplasia, Frontonasal, Type
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16111 ZNF219 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ZNF219 MGD MGI:1917140
Bos taurus ZNF219 VGNC VGNC:37229
Macaca mulatta ZNF219 VGNC VGNC:78876
Rattus norvegicus ZNF219 RGD RGD:1359259
Canis familiaris ZNF219 VGNC VGNC:48675
Felis catus ZNF219 VGNC VGNC:67279
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