AEN - apoptosis enhancing nuclease Gene

中文名称：细胞凋亡增强核酸酶

种属: Homo sapiens

同用名: ISG20L1; pp12744

基因 ID: 64782 | 基因类型: protein coding

关于 AEN

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:88,604,683-88,632,281 (from NCBI)

This gene has 6 transcripts (splice variants), 247 orthologues and 5 paralogues. Ubiquitous expression in gall bladder (RPKM 5.8), thyroid (RPKM 5.8) and 25 other tissues.

功能概要

启用核酸外切酶活性。参与响应 p53 类介质对 DNA 损伤的内在凋亡信号通路和对电离辐射的响应。位于核膜；核仁;和核质。 [由基因组资源联盟提供，2022 年 4 月]

Enables exonuclease activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and response to ionizing radiation. Located in nuclear membrane; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

AEN 基因产物(1)

mRNA	Protein	Name
NM_022767.4	NP_073604.3	apoptosis-enhancing nuclease

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA exonuclease activity	IDA IDA: 通过直接分析推断	18264133	GOA
enables exonuclease activity	IDA IDA: 通过直接分析推断	16171785	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21516116	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA IDA: 通过直接分析推断	18264133	GOA
involved in response to ionizing radiation	IDA IDA: 通过直接分析推断	16171785	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleolus	IDA IDA: 通过直接分析推断	18264133	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	16171785	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AEN 蛋白结构

RNase_T

0
100
200
300
325 a.a.

蛋白主名

其他名称

apoptosis-enhancing nuclease

interferon stimulated exonuclease gene 20kDa-like 1

AEN 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	AEN	Q8WTP8	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	AEN	Q8WTP8	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	AEN	Q8WTP8	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	AEN	Q8WTP8	KRTAP10-5	Homo sapiens	P60370	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	KRTAP10-5	Homo sapiens	P60370	Validated Y2H	25416956
Intra	AEN	Q8WTP8	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	AEN	Q8WTP8	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	AAMP	Homo sapiens	C9JG97	Validated Y2H	25416956
Intra	AEN	Q8WTP8	AAMP	Homo sapiens	C9JG97	Y2H Array	25416956
Intra	AEN	Q8WTP8	MBNL1	Homo sapiens	Q86VM6	Validated Y2H	25416956
Intra	AEN	Q8WTP8	RPGRIP1	Homo sapiens	Q96KN7	Validated Y2H	25416956
Intra	AEN	Q8WTP8	GNPTAB	Homo sapiens	Q3T906	Validated Y2H	25416956
Intra	AEN	Q8WTP8	PDE4DIP	Homo sapiens	Q5VU43	Y2H Array	25416956
Intra	AEN	Q8WTP8	ZNF317	Homo sapiens	Q96PQ6	Y2H Array	31515488
Intra	AEN	Q8WTP8	ZNF317	Homo sapiens	Q96PQ6	Validated Y2H	25416956
Intra	AEN	Q8WTP8	ZNF317	Homo sapiens	Q96PQ6	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	25416956
Intra	AEN	Q8WTP8	EXOSC8	Homo sapiens	Q96B26	Validated Y2H	25416956
Intra	AEN	Q8WTP8	EMD	Homo sapiens	P50402	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	ZFP64	Homo sapiens	Q9NTW7	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	ZFP64	Homo sapiens	Q9NTW7	Y2H Array	25416956
Intra	AEN	Q8WTP8	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
Intra	AEN	Q8WTP8	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	AEN	Q8WTP8	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	AEN	Q8WTP8	TRIM41	Homo sapiens	Q8WV44	Validated Y2H	25416956
Intra	AEN	Q8WTP8	AAMP	Homo sapiens	Q13685	Anti Tag CoIP	33961781
Intra	AEN	Q8WTP8	AAMP	Homo sapiens	Q13685	Y2H Array	29892012
Intra	AEN	Q8WTP8	ZBTB43	Homo sapiens	O43298	Validated Y2H	25416956
Intra	AEN	Q8WTP8	ZBTB43	Homo sapiens	O43298	Y2H Array	25416956
Intra	AEN	Q8WTP8	ZBTB43	Homo sapiens	O43298	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	AEN	Q8WTP8	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	AEN	Q8WTP8	RALYL	Homo sapiens	Q86SE5	Y2H Array	25416956
Intra	AEN	Q8WTP8	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	25416956
Intra	AEN	Q8WTP8	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	AEN	Q8WTP8	IKZF1	Homo sapiens	Q13422	Y2H Array	25416956
Intra	AEN	Q8WTP8	IKZF1	Homo sapiens	Q13422	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	ZNF473	Homo sapiens	Q8WTR7	Validated Y2H	25416956
Intra	AEN	Q8WTP8	ZNF473	Homo sapiens	Q8WTR7	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	ZNF473	Homo sapiens	Q8WTR7	Y2H Array	31515488
Intra	AEN	Q8WTP8	RBMY1A1	Homo sapiens	P0DJD3	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Chest Wall Lymphoma

Chest Wall Cancer	Lymphoma Of Chest Wall
Lymphoma Of The Chest Wall	Malignant Neoplasm Of Chest Wall
Malignant Tumor Of Chest Wall

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00424	AEN Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	AEN	RGD	RGD:1305051
Mus musculus	AEN	MGD	MGI:1915298
Canis familiaris	AEN	VGNC	VGNC:53144
Macaca mulatta	AEN	VGNC	VGNC:84297
Felis catus	AEN	VGNC	VGNC:59664
Bos taurus	AEN	VGNC	VGNC:25705
Others	AEN	NCBI

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