PHF5A - PHD finger protein 5A Gene

中文名称：PHD 指蛋白 5A

种属: Homo sapiens

同用名: INI; Rds3; SF3B7; SAP14b; SF3b14b; bK223H9.2

关于 PHF5A

功能概要

该基因编码剪接因子 3b 蛋白复合物的一个亚基。剪接因子 3b 与剪接因子 3a 和一个 12S RNA 单元一起形成 U2 小核糖核蛋白复合物 (U2 snRNP) 。剪接因子 3b/3a 复合物以序列独立的方式结合内含子分支位点上游的前体 mRNA，并可能将 U2 snRNP 锚定到前体 mRNA。由该基因编码的蛋白质包含一个 PHD 指样结构域，其两侧是高度碱性的 N 和 C 末端。该蛋白属于 PHD-finger 超家族，可作为染色质相关蛋白。该基因在不同的染色体上有几个假基因。[RefSeq 提供，2008 年 7 月]

This gene encodes a subunit of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. The protein encoded by this gene contains a PHD-finger-like domain that is flanked by highly basic N- and C-termini. This protein belongs to the PHD-finger superfamily and may act as a chromatin-associated protein. This gene has several pseudogenes on different chromosomes. [provided by RefSeq, Jul 2008]