DDX23 - DEAD-box helicase 23 Gene

中文名称：死盒解旋酶 23

种属: Homo sapiens

同用名: prp28; PRPF28; U5-100K; SNRNP100; U5-100KD

关于 DDX23

功能概要

该基因编码 DEAD box 蛋白家族的一个成员。以保守基序 Asp-Glu-Ala-Asp (DEAD) 为特征的 DEAD 盒蛋白是推定的 RNA 解旋酶。它们涉及许多涉及 RNA 二级结构改变的细胞过程，例如翻译起始、核和线粒体剪接以及核糖体和剪接体组装。根据它们的分布模式，该家族的一些成员被认为参与了胚胎发生、精子发生以及细胞生长和分裂。该基因编码的蛋白质是 U5 snRNP 复合体的组成部分；它可能促进核 pre-mRNA 剪接过程中剪接体的构象变化。已发现该基因的选择性剪接转录变体，但其生物学有效性尚未确定。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]