2. Gene
  3. SNRNP40 - small nuclear ribonucleoprotein U5 subunit 40 Gene

SNRNP40 - small nuclear ribonucleoprotein U5 subunit 40 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：小核核糖核蛋白 U5 亚基 40

种属: Homo sapiens

同用名: 40K; SPF38; WDR57; PRP8BP; HPRP8BP; PRPF8BP

基因 ID: 9410 | 基因类型: protein coding

关于 SNRNP40

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:31,259,568-31,296,788 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 26 paralogues. Ubiquitous expression in lymph node (RPKM 17.2), testis (RPKM 14.1) and 25 other tissues.

功能概要

该基因编码 U5 小核糖核蛋白 (snRNP) 颗粒的一个组成部分。 U5 snRNP 是剪接体的一部分，剪接体是一种多蛋白复合物，可催化从前信使 RNA 中去除内含子。[RefSeq 提供，2008 年 7 月]

This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs. [provided by RefSeq, Jul 2008]

SNRNP40 基因产物(1)

mRNA Protein Name
NM_004814.3 NP_004805.2 U5 small nuclear ribonucleoprotein 40 kDa protein
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9774689 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of U2-type catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
28076346 GOA
part of U4/U6 x U5 tri-snRNP complex IPI
IPI: 通过物理相互作用推断
30975767 GOA
part of catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
11991638 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SNRNP40 蛋白结构

WD40

WD40: WD domain, G-beta repeat (61 - 94)

WD40

WD40: WD domain, G-beta repeat (103 - 137)

WD40

WD40: WD domain, G-beta repeat (142 - 180)

WD40

WD40: WD domain, G-beta repeat (193 - 221)

WD40

WD40: WD domain, G-beta repeat (226 - 263)

WD40

WD40: WD domain, G-beta repeat (291 - 313)

WD40

WD40: WD domain, G-beta repeat (320 - 351)

  • 0
  • 100
  • 200
  • 300
  • 357 a.a.
蛋白主名 其他名称

U5 small nuclear ribonucleoprotein 40 kDa protein

38 kDa-splicing factor

SNRNP40 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SNRNP40 Q96DI7 SNRNP200 Homo sapiens O75643
Anti Tag CoIP
33961781
Intra SNRNP40 Q96DI7 SNRNP200 Homo sapiens O75643
Anti Tag CoIP
28514442
Intra SNRNP40 Q96DI7 SNRNP200 Homo sapiens O75643
Anti Tag CoIP
35271311
Intra SNRNP40 Q96DI7 SNRNP200 Homo sapiens O75643
Anti Bait CoIP
17353931
Intra SNRNP40 Q96DI7 EFTUD2 Homo sapiens Q15029
Anti Tag CoIP
28514442
Intra SNRNP40 Q96DI7 EFTUD2 Homo sapiens Q15029
Anti Tag CoIP
35271311
Intra SNRNP40 Q96DI7 EFTUD2 Homo sapiens Q15029
Anti Bait CoIP
17353931
Intra SNRNP40 Q96DI7 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra SNRNP40 Q96DI7 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra SNRNP40 Q96DI7 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra SNRNP40 Q96DI7 PRPF8 Homo sapiens Q6P2Q9
Anti Bait CoIP
9774689
Intra SNRNP40 Q96DI7 PRPF8 Homo sapiens Q6P2Q9
Anti Tag CoIP
33961781
Intra SNRNP40 Q96DI7 PRPF8 Homo sapiens Q6P2Q9
Far-WB
9774689
Intra SNRNP40 Q96DI7 PRPF8 Homo sapiens Q6P2Q9
Anti Tag CoIP
28514442
Intra SNRNP40 Q96DI7 PRPF8 Homo sapiens Q6P2Q9
Anti Tag CoIP
35271311
Intra SNRNP40 Q96DI7 PRPF8 Homo sapiens Q6P2Q9
Anti Bait CoIP
17353931
Intra SNRNP40 Q96DI7 DDX23 Homo sapiens Q9BUQ8
Anti Tag CoIP
35271311
Intra SNRNP40 Q96DI7 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra SNRNP40 Q96DI7 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra SNRNP40 Q96DI7 GFAP Homo sapiens P14136
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Burn-Mckeown Syndrome

Choanal Atresia-Hearing Loss-Cardiac Defects-Craniofacial Dysmorphism Syndrome

Oculootofacial Dysplasia

BMKS

Oofd

Bilateral Choanal Atresia, Cardiac Defects, Deafness, And Dysmorphic Appearance

Choanal Atresia - Deafness - Cardiac Defects - Dysmorphism Syndrome

Choanal Atresia Deafness Cardiac Defects Dysmorphism

Oculo-Oto-Facial Dysplasia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13498 SNRNP40 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SNRNP40 MGD MGI:1913835
Felis catus SNRNP40 VGNC VGNC:65534
Bos taurus SNRNP40 VGNC VGNC:35071
Rattus norvegicus SNRNP40 RGD RGD:1309198
Macaca mulatta SNRNP40 VGNC VGNC:100144
Canis familiaris SNRNP40 VGNC VGNC:46607
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