1. Gene
  2. TARS3 - threonyl-tRNA synthetase 3 Gene

TARS3 - threonyl-tRNA synthetase 3 Gene

中文名称:苏氨酰-tRNA 合成酶 3

种属: Homo sapiens

同用名: TARSL2; ThrRS-L

基因 ID: 123283 | 基因类型: protein coding

关于 TARS3

This gene has 7 transcripts (splice variants), 199 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 4.4), heart (RPKM 3.4) and 25 other tissues.

功能概要

预测启用苏氨酸-tRNA 连接酶活性。预计参与苏氨酰-tRNA 氨酰化。预测位于细胞质和细胞核中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable threonine-tRNA Ligase activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TARS3 基因产物(1)

mRNA Protein Name
NM_152334.3 NP_689547.2 threonine--tRNA ligase 2, cytoplasmic
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24312579 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TARS3 蛋白结构

TGS

TGS: TGS domain (167 - 222)

tRNA_SAD

tRNA_SAD: Threonyl and Alanyl tRNA synthetase second additional domain (329 - 377)

tRNA-synt_2b

tRNA-synt_2b: tRNA synthetase class II core domain (G, H, P, S and T) (432 - 594)

HGTP_anticodon

HGTP_anticodon: Anticodon binding domain (699 - 789)

  • 0
  • 200
  • 400
  • 600
  • 802 a.a.
蛋白主名 其他名称

threonine--tRNA ligase 2, cytoplasmic

probable threonine--tRNA ligase 2, cytoplasmic

TARS3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TARS3 A2RTX5 b2rdx5_human Homo sapiens B2RDX5
Validated Y2H
25416956
Intra TARS3 A2RTX5 LGALS14 Homo sapiens Q8TCE9
Validated Y2H
32296183
Intra TARS3 A2RTX5 TARS1 Homo sapiens P26639
Validated Y2H
25416956
Intra TARS3 A2RTX5 TARS1 Homo sapiens P26639
Validated Y2H
32296183
Intra TARS3 A2RTX5 TARS2 Homo sapiens Q9BW92
Validated Y2H
32296183
Intra TARS3 A2RTX5 TP53BP2 Homo sapiens Q05BL1
Validated Y2H
32296183
Intra TARS3 A2RTX5 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra TARS3 A2RTX5 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra TARS3 A2RTX5 ARPC3 Homo sapiens O15145
Validated Y2H
32296183
Intra TARS3 A2RTX5 ATF4 Homo sapiens P18848
Y2H Array
32296183
Intra TARS3 A2RTX5 ATF4 Homo sapiens P18848
Y2H Prey Pooling
32296183
Intra TARS3 A2RTX5 ATF4 Homo sapiens P18848
Validated Y2H
32296183
Intra TARS3 A2RTX5 ECSIT Homo sapiens Q9BQ95
Validated Y2H
32296183
Intra TARS3 A2RTX5 ECSIT Homo sapiens Q9BQ95
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Antisynthetase Syndrome

As Syndrome

Anti-Jo1 Syndrome

Granulomatous Myositis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus TARS3 VGNC VGNC:35606
Rattus norvegicus TARS3 RGD RGD:1311308
Canis familiaris TARS3 VGNC VGNC:47111
Mus musculus TARS3 MGD MGI:2444486
Macaca mulatta TARS3 VGNC VGNC:78205
Felis catus TARS3 VGNC VGNC:65957