CCR10 - C-C motif chemokine receptor 10 Gene

中文名称：CC 基序趋化因子受体 10

种属: Homo sapiens

同用名: GPR2

关于 CCR10

功能概要

趋化因子是一组小的 (大约 8 到 14 kD) ，主要是基本的、结构相关的分子，它们通过与 7 跨膜 G 蛋白偶联受体的一个子集相互作用来调节各种类型白细胞的细胞运输。趋化因子还在免疫系统的发育、稳态和功能中发挥重要作用，并且它们对中枢神经系统的细胞以及参与血管生成或血管抑制的内皮细胞有影响。根据 4 个保守半胱氨酸残基中前 2 个的排列，趋化因子分为 2 个主要亚家族，CXC 和 CC； 2 个半胱氨酸在 CXC 趋化因子中由一个氨基酸分隔，在 CC 趋化因子中相邻。 CCR10 是 CCL27 的受体 (SCYA27；MIM 604833) ； CCR10-CCL27 相互作用涉及 T 细胞介导的皮肤炎症 (Homey 等人，2002 [PubMed 11821900]) 。[OMIM 提供，2008 年 3 月]

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC Chemokines and are adjacent in CC Chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]