Mca-PLAQAV-Dpa-RSSSR-NH2 

Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE; ADAM17), ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis^[1].

1638.70

C₆₉H₁₀₃N₂₃O₂₄

192723-42-5

{Mca}-Pro-Leu-Ala-Gln-Ala-Val-{Dpa}-Arg-Ser-Ser-Ser-Arg-NH2

{Mca}-PLAQAV-{Dpa}-RSSSR-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yi Wang, et al. Protease assay method using site-specific fluorescence dye labeled protein as substrate. US9708638. 2017.

  [2]. Haga S, et al. TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds. Antiviral Res. 2010 Mar;85(3):551-5.  [Content Brief]

  [3]. Inoshima N, et al. Genetic requirement for ADAM10 in severe Staphylococcus aureus skin infection. J Invest Dermatol. 2012 May;132(5):1513-6.  [Content Brief]

  [4]. Liang T, et al. KID24, an antibody directed against ADAM9, is a potent inhibitor of tumor growth in vivo[J]. Molecular Cancer Therapeutics, 2007, 6(11_Supplement): C32-C32.