2. MAPK/ERK Pathway Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. MAPKAPK2 (MK2) HSP
  4. MK2-IN-1

MK2-IN-1 (compound 1) 是一种有效的选择性 MAPKAPK2 (MK2) 抑制剂，对 MK2 的 IC50 为 0.11 uM，对 pHSP27 的 EC50 为 0.35 uM。MK2-IN-1 损害 Tfcp2l1 蛋白中丝氨酸残基的磷酸化水平。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 MK2-IN-1 hydrochloride 通常具有更好的水溶性和稳定性。

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MK2-IN-1 Chemical Structure

MK2-IN-1 Chemical Structure

CAS No. : 1314118-92-7

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MK2-IN-1 的其他形式现货产品:

Other Forms of MK2-IN-1:

MK2-IN-1 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MK2-IN-1 (compound 1) is a potent and selecitve MAPKAPK2 (MK2) inhibitor with an IC50 of 0.11 uM for MK2 and an EC50 of 0.35 uM for pHSP27. MK2-IN-1 impaires the phosphorylation level of serine residues in the Tfcp2l1 protein[1][2].

体外研究
(In Vitro)

MK2-IN-1 (购自 MCE；5 μM；0.5-8 h) 逐渐增加 Tfcp2l1 蛋白水平，2 小时内 Tfcp2l1 转录物水平没有变化[2]。
MK2-IN-1 在短时间内比其他因子诱导更多的碱性磷酸酶 (AP) 阳性集落[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MK2-IN-1 相关抗体:

Western Blot Analysis[2]

Cell Line: 46C mouse embryonic stem cells (mESCs)
Concentration: 5 μM
Incubation Time: 0.5, 1, 2, 8 h
Result: The Tfcp2l1 protein level gradually increased without a change in the Tfcp2l1 transcript level within 2 h.
分子量

472.97

Formula

C27H25ClN4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MK2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK2-IN-11314118-92-7MAPKAPK2 (MK2)HSPMitogen-activated protein kinase activated protein kinase 2MAP kinase activated protein kinase 2MAPK activated protein kinase 2MAPKAP kinase 2Heat shock proteinsMK2pHSP27phosphorylationserineTfcp2l1alkaline phosphataseInhibitorinhibitorinhibit

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目录号：
HY-12834
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