RNF111 - ring finger protein 111 Gene

中文名称：无名指蛋白 111

种属: Homo sapiens

同用名: ARK; hRNF111

关于 RNF111

功能概要

该基因编码的蛋白质是一个含有 E3 泛素连接酶的核 RING 结构域。该蛋白通过促进负调节因子 (如 SMAD 蛋白) 的泛素化和蛋白体降解，与转化生长因子 (TGF) -β/NODAL 信号通路相互作用，从而增强 TGF-β 靶基因转录。作为节点信号级联的调节剂，该基因在胚胎发育过程中的中胚层诱导中起着关键作用。该基因的可变剪接导致编码不同亚型的多个转录变体。[RefSeq 提供，2012 年 7 月]

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin Ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]