2. Gene
  3. TRAF3IP2 - TRAF3 interacting protein 2 Gene

TRAF3IP2 - TRAF3 interacting protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TRAF3 相互作用蛋白 2

种属: Homo sapiens

同用名: ACT1; CIKS; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; PSORS13

基因 ID: 10758 | 基因类型: protein coding

关于 TRAF3IP2

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:111,555,381-111,605,878 (from NCBI)

This gene has 21 transcripts (splice variants), 91 orthologues and is associated with 3 phenotypes. Ubiquitous expression in endometrium (RPKM 6.1), stomach (RPKM 4.8) and 25 other tissues.

功能概要

该基因编码一种蛋白质，该蛋白质参与调节 Rel/NF-kappaB 转录因子家族成员对细胞因子的反应。这些因素在响应病原体、炎症信号和压力的先天免疫中起着核心作用。该基因产物与 TRAF 蛋白 (肿瘤坏死因子受体相关因子) 和 I-kappaB 激酶或 MAP 激酶相互作用，以激活 NF-kappaB 或 Jun 激酶。已经确定了几种编码不同亚型的替代转录本。已经鉴定出另一种不编码蛋白质并以相反方向转录的转录物。该转录物的过表达已被证明可以减少至少一种蛋白质编码转录物的表达，表明它在该基因的表达中具有调节作用。[RefSeq 提供，2009 年 8 月]

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]

TRAF3IP2 基因产物(4)

mRNA Protein Name
NM_001164281.3 NP_001157753.1 E3 ubiquitin ligase TRAF3IP2 isoform 3
NM_001164283.3 NP_001157755.1 E3 ubiquitin ligase TRAF3IP2 isoform 5
NM_147200.3 NP_671733.2 E3 ubiquitin ligase TRAF3IP2 isoform 1
NM_147686.4 NP_679211.2 E3 ubiquitin ligase TRAF3IP2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12459498 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
19825828 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in inflammatory response IDA
IDA: 通过直接分析推断
17277779 GOA
involved in interleukin-17-mediated signaling pathway IMP
IMP: 通过突变表型推断
19825828 GOA
involved in interleukin-17A-mediated signaling pathway IDA
IDA: 通过直接分析推断
17277779 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IEP
IEP: 通过表达模式推断
12761501 GOA
involved in positive regulation of defense response to virus by host IDA
IDA: 通过直接分析推断
23066157 GOA
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
19825828 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRAF3IP2 蛋白结构

SEFIR

SEFIR: SEFIR domain (410 - 552)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 574 a.a.
蛋白主名 其他名称

E3 ubiquitin ligase TRAF3IP2

E3 ubiquitin-protein ligase CIKS

TRAF3IP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TRAF3IP2 O43734 RIMBP3 Homo sapiens Q9UFD9
Y2H Array
25416956
Intra TRAF3IP2 O43734 FHL3 Homo sapiens Q96C98
Y2H Prey Pooling
25416956
Intra TRAF3IP2 O43734 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
25416956
Intra TRAF3IP2 O43734 MRPL28 Homo sapiens Q13084
Validated Y2H
25416956
Intra TRAF3IP2 O43734 MRPL28 Homo sapiens Q13084
Y2H Prey Pooling
25416956
Intra TRAF3IP2 O43734 MRPL28 Homo sapiens Q13084
Y2H Array
25416956
Intra TRAF3IP2 O43734 TRIP6 Homo sapiens Q15654
Y2H Array
25416956
Intra TRAF3IP2 O43734 STK16 Homo sapiens O75716
Validated Y2H
25416956
Intra TRAF3IP2 O43734 STK16 Homo sapiens O75716
Y2H Array
25416956
Intra TRAF3IP2 O43734 STK16 Homo sapiens O75716
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Candidiasis, Familial, 8

CANDF8

Candidiasis, Familial Chronic Mucocutaneous, Autosomal Recessive

Candidiasis Familial Chronic Mucocutaneous Autosomal Recessive

Candidiasis, Familial, Type 8
Psoriasis 13

PSORS13

Psoriasis 13, Susceptibility To

Psoriasis

Psoriasis Vulgaris

Psoriasis Susceptibility 13

Pv

Psoriasis, Susceptibility To, Type 13
Discoid Lupus Erythematosus

Lupus Erythematosus Discoid

Lupus Erythematosus, Discoid

Cdle - [Chronic Discoid Lupus Erythematosus]

Dle - [Discoid Lupus Erythematosus]

Chronic Discoid Lupus Erythematosus

Discoid Lupus Nos
Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous

Cmc

Candidiasis Chronic Mucocutaneous
Candidiasis

Systemic Candidiasis

Invasive Candidiasis

Disseminated Candidiasis

Systemic Candida Infections

Candidiasis, Invasive
Folliculitis
Pericarditis
Immunodeficiency 29

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12b Deficiency

IMD29

Il12b Deficiency

Immunodeficiency 29, Mycobacteriosis

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interleukin 12b Deficiency

Msmd Due To Complete Il12b Deficiency

Msmd Due To Complete Interleukin 12b Deficiency

Immunodeficiency, Type 29, Mycobacteriosis
Psoriasis
Psoriasis 10

PSORS10

Psoriasis Susceptibility 10

Psoriasis 10, Susceptibility To
Candidal Paronychia

Candidiasis Of Skin

Candidiasis Of Skin And Nails

Candidal Perionyxis
Psoriasis 7

PSORS7

Psoriasis 7, Susceptibility To

Psoriasis Susceptibility 7

Psoriasis

Psoriasis Vulgaris

Pv
Nail Disease

Nail Diseases

Abnormality Of The Nail

Nail Anomaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-NP135 Oxidized low density lipoprotein (Human) / 否
HY-RS14971 TRAF3IP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TRAF3IP2 VGNC VGNC:36274
Mus musculus TRAF3IP2 MGD MGI:2143599
Macaca mulatta TRAF3IP2 VGNC VGNC:78921
Felis catus TRAF3IP2 VGNC VGNC:66498
Rattus norvegicus TRAF3IP2 RGD RGD:1593240
Canis familiaris TRAF3IP2 VGNC VGNC:47766
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