2. Gene
  3. ULK1 - unc-51 like autophagy activating kinase 1 Gene

ULK1 - unc-51 like autophagy activating kinase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：unc-51 样自噬激活激酶 1

种属: Homo sapiens

同用名: ATG1; ATG1A; UNC51; hATG1; Unc51.1

基因 ID: 8408 | 基因类型: protein coding

关于 ULK1

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:131,894,622-131,923,150 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 14.9), endometrium (RPKM 11.7) and 25 other tissues.

功能概要

实现相同的蛋白质结合活性；蛋白丝氨酸/苏氨酸激酶活性；和小的 GTPase 结合活性。参与多个过程，包括自噬体组装；共生体对宿主自噬的正调控；和蛋白质磷酸化。位于自噬体；胞质溶胶；和吞噬泡组装位点膜。是自噬体膜的外在成分； omegasome 膜的外在成分；和吞噬细胞组装位点膜的外在成分。 Atg1/ULK1 激酶复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including autophagosome assembly; positive regulation by symbiont of host autophagy; and protein phosphorylation. Located in autophagosome; cytosol; and phagophore assembly site membrane. Is extrinsic component of autophagosome membrane; extrinsic component of omegasome membrane; and extrinsic component of phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Apr 2022]

ULK1 基因产物(4)

mRNA Protein Name
XM_011538799.3 XP_011537101.1 serine/threonine-protein kinase ULK1 isoform X2
XM_011538798.4 XP_011537100.1 serine/threonine-protein kinase ULK1 isoform X1
XR_007063134.1
NM_003565.4 NP_003556.2 serine/threonine-protein kinase ULK1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase binding IPI
IPI: 通过物理相互作用推断
25891078 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
20562859 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11146101 GOA
enables protein serine/threonine kinase activity EXP
EXP: 通过实验结果推断
32320653 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
18936157 GOA
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
19211835 GOA
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
22613832 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in autophagosome assembly IDA
IDA: 通过直接分析推断
19225151 GOA
involved in autophagy IDA
IDA: 通过直接分析推断
18936157 GOA
involved in autophagy IGI
IGI: 通过遗传相互作用推断
28389568 GOA
involved in autophagy IMP
IMP: 通过突变表型推断
17595159 GOA
involved in cellular response to stress IDA
IDA: 通过直接分析推断
25891078 GOA
involved in macroautophagy IMP
IMP: 通过突变表型推断
22354037 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
21795849 GOA
involved in negative regulation of protein-containing complex assembly IDA
IDA: 通过直接分析推断
25126726 GOA
involved in neuron projection development IMP
IMP: 通过突变表型推断
18007665 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
25126726 GOA
involved in peptidyl-threonine phosphorylation IDA
IDA: 通过直接分析推断
27103069 GOA
involved in positive regulation of autophagy IDA
IDA: 通过直接分析推断
25126726 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
18936157 GOA
involved in protein localization IMP
IMP: 通过突变表型推断
16940348 GOA
involved in regulation of macroautophagy IDA
IDA: 通过直接分析推断
20921139 GOA
involved in regulation of protein lipidation IDA
IDA: 通过直接分析推断
19225151 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Atg1/ULK1 kinase complex IPI
IPI: 通过物理相互作用推断
19211835 GOA
located in autophagosome IDA
IDA: 通过直接分析推断
17595159 GOA
located in autophagosome membrane IDA
IDA: 通过直接分析推断
22885598 GOA
is active in cytoplasm IDA
IDA: 通过直接分析推断
29487085 GOA
located in cytosol IDA
IDA: 通过直接分析推断
11146101 GOA
located in omegasome membrane IDA
IDA: 通过直接分析推断
22885598 GOA
located in phagophore assembly site IDA
IDA: 通过直接分析推断
19597335 GOA
located in phagophore assembly site membrane IDA
IDA: 通过直接分析推断
18936157 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ULK1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (18 - 278)

DUF3543

DUF3543: Domain of unknown function (DUF3543) (833 - 1045)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1050 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase ULK1

ATG1 autophagy related 1 homolog

autophagy-related protein 1 homolog

ULK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ULK1 O75385 NTRK1 Homo sapiens P04629
Anti Tag CoIP
17389358
Intra ULK1 O75385 RB1CC1 Homo sapiens Q8TDY2
Pull Down
32707033
Intra ULK1 O75385 RB1CC1 Homo sapiens Q8TDY2
Anti Bait CoIP
23524951
Intra ULK1 O75385 RB1CC1 Homo sapiens Q8TDY2
Anti Tag CoIP
35271311
Intra ULK1 O75385 RB1CC1 Homo sapiens Q8TDY2
Anti Tag CoIP
20562859
Intra ULK1 O75385 RB1CC1 Homo sapiens Q8TDY2
Anti Tag CoIP
25686248
Intra ULK1 O75385 RB1CC1 Homo sapiens Q8TDY2
Anti Tag CoIP
33422265
Intra ULK1 O75385 RB1CC1 Homo sapiens Q8TDY2
Crosslink
23392225
Intra ULK1 O75385 RPTOR Homo sapiens Q8N122
Anti Tag CoIP
25686248
Intra ULK1 O75385 AMBRA1 Homo sapiens Q9C0C7-3
Anti Tag CoIP
23524951
Intra ULK1 O75385 AMBRA1 Homo sapiens Q9C0C7-3
Anti Bait CoIP
23524951
Intra ULK1 O75385 C9orf72 Homo sapiens Q96LT7-1
Pull Down
27334615
Intra ULK1 O75385 C9orf72 Homo sapiens Q96LT7-1
PLA
27334615
Intra ULK1 O75385 C9orf72 Homo sapiens Q96LT7-1
Anti Tag CoIP
27334615
Intra ULK1 O75385 C9orf72 Homo sapiens Q96LT7-2
PLA
27334615
Intra ULK1 O75385 C9orf72 Homo sapiens Q96LT7-2
Anti Tag CoIP
27334615
Intra ULK1 O75385 C9orf72 Homo sapiens Q96LT7-2
Pull Down
27334615
Intra ULK1 O75385 AMBRA1 Homo sapiens Q9C0C7
Anti Bait CoIP
23524951
Intra ULK1 O75385 MAP1LC3C Homo sapiens Q9BXW4
Pull Down
20562859
Intra ULK1 O75385 TBC1D14 Homo sapiens Q9P2M4
Y2H
22613832
Intra ULK1 O75385 TBC1D14 Homo sapiens Q9P2M4
Anti Tag CoIP
22613832
Intra ULK1 O75385 ATG13 Homo sapiens O75143
Anti Bait CoIP
23524951
Intra ULK1 O75385 ATG13 Homo sapiens O75143
Anti Tag CoIP
33450483
Intra ULK1 O75385 ATG13 Homo sapiens O75143
Anti Tag CoIP
25686248
Intra ULK1 O75385 ATG13 Homo sapiens O75143
Anti Tag CoIP
20562859
Intra ULK1 O75385 ATG13 Homo sapiens O75143
Crosslink
23392225
Intra ULK1 O75385 ATG13 Homo sapiens O75143
Anti Tag CoIP
33422265
Intra ULK1 O75385 ATG13 Homo sapiens O75143
Pull Down
32707033
Intra ULK1 O75385 MTOR Homo sapiens P42345
Anti Bait CoIP
23524951
Intra ULK1 O75385 MTOR Homo sapiens P42345
Anti Bait CoIP
25686248
Intra ULK1 O75385 MTOR Homo sapiens P42345
Anti Tag CoIP
25686248
Intra ULK1 O75385 TRAF6 Homo sapiens Q9Y4K3
Anti Bait CoIP
23524951
Intra ULK1 O75385 MAP1LC3B Homo sapiens Q9GZQ8
Pull Down
20562859
Intra ULK1 O75385 HTT Homo sapiens P42858
Anti Bait CoIP
25686248
Intra ULK1 O75385 HTT Homo sapiens P42858
Anti Tag CoIP
25686248
Intra ULK1 O75385 PRKAB1 Homo sapiens Q9Y478
Anti Tag CoIP
25686248
Intra ULK1 O75385 PRKAB1 Homo sapiens Q9Y478
Anti Bait CoIP
21072212
Intra ULK1 O75385 GABARAPL2 Homo sapiens P60520
Pull Down
20562859
Intra ULK1 O75385 GABARAPL2 Homo sapiens P60520
Anti Tag CoIP
20562859
Intra ULK1 O75385 GABARAPL1 Homo sapiens Q9H0R8
Pull Down
20562859
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
Acute Laryngopharyngitis

Pharyngolaryngitis

Laryngopharyngitis

Hypopharyngitis
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (18)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-16966 SBI-0206965 Inhibitor 99.39% 否
HY-13018 MRT67307 Inhibitor 99.34% 否
HY-114490 ULK-101 Inhibitor 99.96% 否
HY-101923B LYN-1604 dihydrochloride Activator 99.64% 否
HY-124729 BL-918 Activator 99.98% 否
HY-160699 DCC-3116 Inhibitor 99.25% 否
HY-137742 SBP-7455 Inhibitor 98.24% 否
HY-143466 ULK1-IN-2 Inhibitor 99.09% 否
HY-148063 DB0614 98.80% 否
HY-137506 XST-14 Inhibitor 99.26% 否
HY-148061 DB1113 99.28% 否
HY-101923A LYN-1604 hydrochloride Activator / 否
HY-13018A MRT67307 hydrochloride Inhibitor / 否
HY-101923 LYN-1604 Activator / 否
HY-158408 NZ-66 / 否
HY-161850 ULK1-IN-3 Inhibitor / 否
HY-117413 SR-17398 Inhibitor / 否
HY-162100 MR-2088 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ULK1 VGNC VGNC:36658
Mus musculus ULK1 MGD MGI:1270126
Canis familiaris ULK1 VGNC VGNC:48128
Macaca mulatta ULK1 VGNC VGNC:78715
Felis catus ULK1 VGNC VGNC:66814
Rattus norvegicus ULK1 RGD RGD:1589743
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