RB1CC1 - RB1 inducible coiled-coil 1 Gene

中文名称：RB1 感应线圈 1

种属: Homo sapiens

同用名: CC1; ATG17; FIP200; PPP1R131

基因 ID: 9821 | 基因类型: protein coding

关于 RB1CC1

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:52,622,458-52,714,435 (from NCBI)

This gene has 10 transcripts (splice variants), 223 orthologues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 14.7), brain (RPKM 11.4) and 25 other tissues.

功能概要

该基因编码的蛋白质与信号通路相互作用，协调调节细胞生长、细胞增殖、细胞凋亡、自噬和细胞迁移。这种肿瘤抑制因子还可以增强癌细胞中视网膜母细胞瘤 1 基因的表达。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 11 月]

The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, Apoptosis, Autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in Cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]

RB1CC1 基因产物(2)

mRNA	Protein	Name
NM_001083617.2	NP_001077086.1	RB1-inducible coiled-coil protein 1 isoform 2
NM_014781.5	NP_055596.3	RB1-inducible coiled-coil protein 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	19211835	GOA
enables protein kinase binding	IDA IDA: 通过直接分析推断	19211835	GOA
enables protein-membrane adaptor activity	IDA IDA: 通过直接分析推断	23392225	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in autophagosome assembly	IDA IDA: 通过直接分析推断	19225151	GOA
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	21795849	GOA
involved in regulation of protein lipidation	IDA IDA: 通过直接分析推断	19225151	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Atg1/ULK1 kinase complex	IPI IPI: 通过物理相互作用推断	19211835	GOA
located in lysosome	IDA IDA: 通过直接分析推断	28561066	GOA
is active in phagophore assembly site	IDA IDA: 通过直接分析推断	28561066	GOA
located in phagophore assembly site	IDA IDA: 通过直接分析推断	19597335	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RB1CC1 蛋白结构

ATG11

0
300
600
900
1200
1500
1594 a.a.

蛋白主名

其他名称

RB1-inducible coiled-coil protein 1

200 kDa FAK family kinase-interacting protein

RB1CC1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RB1CC1	Q8TDY2	ATG5	Homo sapiens	Q9H1Y0	Crosslink	23392225
种属内	RB1CC1	Q8TDY2	ATG5	Homo sapiens	Q9H1Y0	Anti Tag CoIP	23262492
种属间	RB1CC1	Q8TDY2	Atg16l1	Mus musculus	Q8C0J2-3	Anti Tag CoIP	23262492
种属内	RB1CC1	Q8TDY2	C9orf72	Homo sapiens	Q96LT7-1	Pull Down	27334615
种属内	RB1CC1	Q8TDY2	C9orf72	Homo sapiens	Q96LT7-1	PLA	27334615
种属内	RB1CC1	Q8TDY2	C9orf72	Homo sapiens	Q96LT7-1	Anti Tag CoIP	27334615
种属内	RB1CC1	Q8TDY2	C9orf72	Homo sapiens	Q96LT7-2	Anti Tag CoIP	27334615
种属内	RB1CC1	Q8TDY2	C9orf72	Homo sapiens	Q96LT7-2	IF	27334615
种属内	RB1CC1	Q8TDY2	C9orf72	Homo sapiens	Q96LT7-2	Pull Down	27334615
种属内	RB1CC1	Q8TDY2	C9orf72	Homo sapiens	Q96LT7-2	PLA	27334615
种属内	RB1CC1	Q8TDY2	ATG13	Homo sapiens	O75143	Anti Tag CoIP	20562859
种属内	RB1CC1	Q8TDY2	ATG13	Homo sapiens	O75143	Crosslink	23392225
种属内	RB1CC1	Q8TDY2	ATG101	Homo sapiens	Q9BSB4	Anti Tag CoIP	20562859
种属内	RB1CC1	Q8TDY2	ATG101	Homo sapiens	Q9BSB4	BioID	34524948
种属内	RB1CC1	Q8TDY2	ATG101	Homo sapiens	Q9BSB4	Crosslink	23392225
种属内	RB1CC1	Q8TDY2	ATG101	Homo sapiens	Q9BSB4	Anti Tag CoIP	19597335
种属内	RB1CC1	Q8TDY2	TBKBP1	Homo sapiens	A7MCY6	Anti Tag CoIP	21903422
种属内	RB1CC1	Q8TDY2	ATG16L1	Homo sapiens	Q676U5	Anti Tag CoIP	20562859
种属内	RB1CC1	Q8TDY2	ATG16L1	Homo sapiens	Q676U5	Crosslink	23392225
种属内	RB1CC1	Q8TDY2	ATG16L1	Homo sapiens	Q676U5	Anti Tag CoIP	23262492
种属内	RB1CC1	Q8TDY2	ULK1	Homo sapiens	O75385	BioID	34524948
种属内	RB1CC1	Q8TDY2	ULK1	Homo sapiens	O75385	Crosslink	23392225
种属内	RB1CC1	Q8TDY2	ULK1	Homo sapiens	O75385	Anti Tag CoIP	20562859

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Vulvar Leiomyoma

Vulvar Benign Neoplasm

Vici Syndrome

Absent Corpus Callosum Cataract Immunodeficiency	VICIS
Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum	Dionisi Vici Sabetta Gambarara Syndrome
Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum	Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome
Dionisi-Vici-Sabetta-Gambarara Syndrome	Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum

Neurodegeneration With Brain Iron Accumulation 5

NBIA5	Beta-Propeller Protein-Associated Neurodegeneration
Bpan	Static Encephalopathy Of Childhood With Neurodegeneration In Adulthood
Senda	Neurodegeneration With Brain Iron Accumulation Type 5
Neurodegeneration With Brain Iron Accululation 5	Static Encephalopathy Of Childhood With Neurdegeneration In Adulthood
Neurodegeneration, With Brain Iron Accululation, Type 5

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11714	RB1CC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	RB1CC1	VGNC	VGNC:64514
Bos taurus	RB1CC1	VGNC	VGNC:33769
Macaca mulatta	RB1CC1	VGNC	VGNC:76483
Canis familiaris	RB1CC1	VGNC	VGNC:45390
Mus musculus	RB1CC1	MGD	MGI:1341850
Rattus norvegicus	RB1CC1	RGD	RGD:1309346

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RB1CC1 - RB1 inducible coiled-coil 1 Gene

关于 RB1CC1

功能概要

RB1CC1 基因产物(2)

RB1CC1 蛋白结构

RB1CC1 蛋白互作信息

关联疾病

直系同源

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RB1CC1 - RB1 inducible coiled-coil 1 Gene

关于 RB1CC1

功能概要

RB1CC1 基因产物(2)

RB1CC1 蛋白结构

RB1CC1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z