ATG13 - autophagy related 13 Gene

中文名称：自噬相关 13

种属: Homo sapiens

同用名: KIAA0652; PARATARG8

基因 ID: 9776 | 基因类型: protein coding

关于 ATG13

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:46,617,553-46,674,518 (from NCBI)

This gene has 31 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in testis (RPKM 17.3), brain (RPKM 12.2) and 25 other tissues.

功能概要

该基因编码的蛋白质是自噬因子和 TOR 激酶信号通路的靶标。编码的蛋白质对于自噬体形成和线粒体自噬至关重要。[RefSeq 提供，2016 年 10 月]

The protein encoded by this gene is an Autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and Mitophagy. [provided by RefSeq, Oct 2016]

ATG13 基因产物(51)

mRNA	Protein	Name
NM_001142673.3	NP_001136145.1	autophagy-related protein 13 isoform c
NM_001205119.2	NP_001192048.1	autophagy-related protein 13 isoform a
NM_001205120.2	NP_001192049.1	autophagy-related protein 13 isoform c
NM_001205121.2	NP_001192050.1	autophagy-related protein 13 isoform f
NM_001205122.2	NP_001192051.1	autophagy-related protein 13 isoform h
NM_001346311.2	NP_001333240.1	autophagy-related protein 13 isoform a
NM_001346312.2	NP_001333241.1	autophagy-related protein 13 isoform a
NM_001346313.2	NP_001333242.1	autophagy-related protein 13 isoform a
NM_001346314.2	NP_001333243.1	autophagy-related protein 13 isoform a
NM_001346315.2	NP_001333244.1	autophagy-related protein 13 isoform a
NM_001346316.2	NP_001333245.1	autophagy-related protein 13 isoform a
NM_001346317.2	NP_001333246.1	autophagy-related protein 13 isoform b
NM_001346318.2	NP_001333247.1	autophagy-related protein 13 isoform b
NM_001346319.2	NP_001333248.1	autophagy-related protein 13 isoform c
NM_001346320.2	NP_001333249.1	autophagy-related protein 13 isoform c
NM_001346321.2	NP_001333250.1	autophagy-related protein 13 isoform c
NM_001346322.2	NP_001333251.1	autophagy-related protein 13 isoform c
NM_001346323.2	NP_001333252.1	autophagy-related protein 13 isoform c
NM_001346324.2	NP_001333253.1	autophagy-related protein 13 isoform c
NM_001346325.2	NP_001333254.1	autophagy-related protein 13 isoform c
NM_001346326.2	NP_001333255.1	autophagy-related protein 13 isoform c
NM_001346327.2	NP_001333256.1	autophagy-related protein 13 isoform c
NM_001346328.2	NP_001333257.1	autophagy-related protein 13 isoform c
NM_001346329.2	NP_001333258.1	autophagy-related protein 13 isoform c
NM_001346330.2	NP_001333259.1	autophagy-related protein 13 isoform c
NM_001346331.2	NP_001333260.1	autophagy-related protein 13 isoform c
NM_001346332.2	NP_001333261.1	autophagy-related protein 13 isoform c
NM_001346333.2	NP_001333262.1	autophagy-related protein 13 isoform d
NM_001346334.2	NP_001333263.1	autophagy-related protein 13 isoform d
NM_001346335.2	NP_001333264.1	autophagy-related protein 13 isoform d
NM_001346336.2	NP_001333265.1	autophagy-related protein 13 isoform d
NM_001346337.2	NP_001333266.1	autophagy-related protein 13 isoform d
NM_001346338.2	NP_001333267.1	autophagy-related protein 13 isoform e
NM_001346340.2	NP_001333269.1	autophagy-related protein 13 isoform e
NM_001346342.2	NP_001333271.1	autophagy-related protein 13 isoform f
NM_001346344.2	NP_001333273.1	autophagy-related protein 13 isoform f
NM_001346346.2	NP_001333275.1	autophagy-related protein 13 isoform f
NM_001346348.2	NP_001333277.1	autophagy-related protein 13 isoform f
NM_001346349.2	NP_001333278.1	autophagy-related protein 13 isoform f
NM_001346350.2	NP_001333279.1	autophagy-related protein 13 isoform f
NM_001346351.2	NP_001333280.1	autophagy-related protein 13 isoform f
NM_001346352.2	NP_001333281.1	autophagy-related protein 13 isoform f
NM_001346353.2	NP_001333282.1	autophagy-related protein 13 isoform f
NM_001346354.2	NP_001333283.1	autophagy-related protein 13 isoform f
NM_001346355.2	NP_001333284.1	autophagy-related protein 13 isoform g
NM_001346356.2	NP_001333285.1	autophagy-related protein 13 isoform g
NM_001346357.2	NP_001333286.1	autophagy-related protein 13 isoform i
NM_001346358.2	NP_001333287.1	autophagy-related protein 13 isoform i
NM_001346359.2	NP_001333288.1	autophagy-related protein 13 isoform i
NM_001346360.2	NP_001333289.1	autophagy-related protein 13 isoform j
NM_014741.5	NP_055556.2	autophagy-related protein 13 isoform f

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	19211835	GOA
enables protein kinase binding	IDA IDA: 通过直接分析推断	29487085	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	18936157	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: 通过直接分析推断	19225151	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in autophagosome assembly	IDA IDA: 通过直接分析推断	19225151	GOA
acts upstream of or within autophagosome assembly	IMP IMP: 通过突变表型推断	19211835	GOA
involved in autophagosome assembly	IMP IMP: 通过突变表型推断	19211835	GOA
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	21795849	GOA
involved in positive regulation of autophagy	IDA IDA: 通过直接分析推断	29487085	GOA
involved in regulation of protein lipidation	IDA IDA: 通过直接分析推断	19225151	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Atg1/ULK1 kinase complex	IPI IPI: 通过物理相互作用推断	19211835	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	21855797	GOA
located in phagophore assembly site	IDA IDA: 通过直接分析推断	19597335	GOA
is active in phagophore assembly site membrane	IDA IDA: 通过直接分析推断	19597335	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ATG13 蛋白结构

ATG13

0
100
200
300
400
517 a.a.

蛋白主名

其他名称

autophagy-related protein 13

ATG13 autophagy related 13 homolog

ATG13 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ATG13	O75143	RB1CC1	Homo sapiens	Q8TDY2	Anti Tag CoIP	20562859
种属内	ATG13	O75143	RB1CC1	Homo sapiens	Q8TDY2	Anti Bait CoIP	33368531
种属内	ATG13	O75143	RB1CC1	Homo sapiens	Q8TDY2	Anti Bait CoIP	19597335
种属内	ATG13	O75143	RB1CC1	Homo sapiens	Q8TDY2	Anti Tag CoIP	35271311
种属内	ATG13	O75143	RB1CC1	Homo sapiens	Q8TDY2	Crosslink	23392225
种属内	ATG13	O75143	MAP1LC3A	Homo sapiens	Q9H492-1	SPR	24290141
种属内	ATG13	O75143	MAP1LC3A	Homo sapiens	Q9H492-1	Y2H	24290141
种属内	ATG13	O75143	MAP1LC3A	Homo sapiens	Q9H492-1	Pull Down	24290141
种属内	ATG13	O75143	C9orf72	Homo sapiens	Q96LT7-1	Pull Down	27334615
种属内	ATG13	O75143	C9orf72	Homo sapiens	Q96LT7-2	Pull Down	27334615
种属内	ATG13	O75143	C9orf72	Homo sapiens	Q96LT7-2	PLA	27334615
种属内	ATG13	O75143	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
种属内	ATG13	O75143	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	24290141
种属内	ATG13	O75143	MAP1LC3C	Homo sapiens	Q9BXW4	SPR	24290141
种属内	ATG13	O75143	MAP1LC3C	Homo sapiens	Q9BXW4	Y2H	24290141
种属内	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	Anti Tag CoIP	20562859
种属内	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	Ion Exchange Chrom	26299944
种属内	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	Anti Bait CoIP	19597335
种属内	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	X-Ray Diffraction	26299944
种属内	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	Pull Down	26299944
种属内	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	Y2H	24290141
种属内	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	GMS	26299944
种属内	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	Anti Tag CoIP	19597335
种属内	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	Anti Tag CoIP	35271311
种属内	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	BioID	34524948
种属内	ATG13	O75143	ATG101	Homo sapiens	Q9BSB4	Crosslink	23392225
种属内	ATG13	O75143	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
种属内	ATG13	O75143	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	24290141
种属内	ATG13	O75143	MAP1LC3B	Homo sapiens	Q9GZQ8	SPR	24290141
种属内	ATG13	O75143	GABARAP	Homo sapiens	O95166	Y2H	24290141
种属内	ATG13	O75143	GABARAP	Homo sapiens	O95166	Pull Down	20562859
种属内	ATG13	O75143	OFD1	Homo sapiens	O75665	IF	33368531
种属内	ATG13	O75143	OFD1	Homo sapiens	O75665	Pull Down	33368531
种属内	ATG13	O75143	OFD1	Homo sapiens	O75665	Anti Bait CoIP	33368531
种属内	ATG13	O75143	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
种属内	ATG13	O75143	GABARAPL2	Homo sapiens	P60520	Anti Tag CoIP	35271311
种属内	ATG13	O75143	GABARAPL2	Homo sapiens	P60520	Y2H	21900206
种属内	ATG13	O75143	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
种属内	ATG13	O75143	ULK1	Homo sapiens	O75385	BioID	34524948
种属内	ATG13	O75143	ULK1	Homo sapiens	O75385	Crosslink	23392225
种属内	ATG13	O75143	ULK1	Homo sapiens	O75385	Anti Tag CoIP	23524951
种属内	ATG13	O75143	ULK1	Homo sapiens	O75385	Anti Tag CoIP	35271311
种属内	ATG13	O75143	ULK1	Homo sapiens	O75385	Anti Bait CoIP	19597335

种属间: 跨种属相互作用 种属内: 同种属相互作用

ATG13 抗体

目录号	产品名	应用	反应物种
HY-P81905	ATG13 Antibody (YA1650)	WB, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Liver Carcinoma In Situ

Carcinoma In Situ Of Liver And Biliary System

Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts

Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2	CMT2E
CMT2S	CMT2Y
Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Disease Type 2y
Charcot-Marie-Tooth Disease Axonal Type 2s	Charcot-Marie-Tooth Disease, Axonal, Type 2s
Charcot-Marie-Tooth Disease, Type 2e	Hereditary Motor And Sensory Neuropathy Type 2
Charcot-Marie-Tooth Neuropathy, Type 2s	Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s
Charcot-Marie-Tooth Disease, Axonal, Type 2y	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y
Charcot-Marie-Tooth Neuropathy, Type 2y	Charcot-Marie-Tooth Disease, Type 2y
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Neuropathy Type 2e
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation	Cmt2 Due To Vcp Mutation
Charcot-Marie-Tooth Disease Type 2s	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease	Cmt2
Charcot-Marie-Tooth Neuropathy, Type 2e	Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type
Hereditary Motor And Sensory Neuropathy Okinawa Type	Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y
Charcot-Marie-Tooth Neuropathy Type 2y	Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s
Charcot-Marie-Tooth Neuropathy Type 2s	Charcot-Marie-Tooth Type 2
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y	Charcot-Marie-Tooth Disease 2e
Charcot-Marie-Tooth Disease Axonal Type 2e	Charcot-Marie-Tooth Disease Neuronal Type 2e
Charcot-Marie-Tooth Disease 2s	Charcot-Marie-Tooth Neuropathy Axonal Type 2s
Charcot-Marie-Tooth Disease 2y	Charcot-Marie-Tooth Disease, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01141	ATG13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ATG13	VGNC	VGNC:38217
Macaca mulatta	ATG13	VGNC	VGNC:70148
Bos taurus	ATG13	VGNC	VGNC:26251
Rattus norvegicus	ATG13	RGD	RGD:1310685
Felis catus	ATG13	VGNC	VGNC:59996
Mus musculus	ATG13	MGD	MGI:1196429

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ATG13 - autophagy related 13 Gene

关于 ATG13

功能概要

ATG13 基因产物(51)

ATG13 蛋白结构

ATG13 蛋白互作信息

ATG13 抗体

关联疾病

直系同源

热门区域

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ATG13 - autophagy related 13 Gene

关于 ATG13

功能概要

ATG13 基因产物(51)

ATG13 蛋白结构

ATG13 蛋白互作信息

ATG13 抗体

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

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J

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Q

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