2. Autophagy Apoptosis Cell Cycle/DNA Damage Epigenetics NF-κB PI3K/Akt/mTOR Metabolic Enzyme/Protease Immunology/Inflammation
  3. ULK Apoptosis PARP Autophagy NF-κB AMPK Akt Reactive Oxygen Species
  4. ULK1-IN-3

ULK1-IN-3 (Compound 8) 是一种新型基于色酮的潜在的 ULK1 抑制剂。ULK1-IN-3 抑制结肠癌细胞系细胞周期，自噬和诱导凋亡，氧化应激。

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ULK1-IN-3 Chemical Structure

ULK1-IN-3 Chemical Structure

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Customer Review

ULK1-IN-3 相关抗体

Top Publications Citing Use of Products

查看 ULK 亚型特异性产品:

查看所有亚型
ULK1 ULK2

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 AMPK 亚型特异性产品:

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ULK1-IN-3 (Compound 8) is a novel chromone-based as a potential inhibitor of ULK1. ULK1-IN-3 inhibits cell cycle, autophagy and induces apoptosis, oxidative stress in colon cancer cell lines[1].

IC50 & Target

ULK1

 

体外研究
(In Vitro)

ULK1-IN-3 (0-20 μM, 72 小时) 对 786-O, MCF-7, SW620 和 T-24 结肠癌细胞系均具有有效的生长抑制作用，且对 SW620 细胞最有效，LC50值为 3.2 μM，效力略高于 5-Fluorouracil (HY-90006)[1]。
ULK1-IN-3 (1.25-10 μM, 24 小时) 诱导 SW620 细胞 G2/M 和 S 期细胞阻滞[1].
ULK1-IN-3 (1.25-5 μM, 48 小时) 在 SW620 细胞中可能通过提高 ROS 的产生触发经典的凋亡途径。此外，ULK1-IN-3 上调 SW620细胞中 cleaved PARP (cPARP) 和 NFκβ，AMPK 的表达，但下调 AKT 的表达[1].

ULK1-IN-3 对癌细胞活力抑制作用的 LC50 值[1]

Compounds 786-O MCF-7 SW620 T-24
ULK1-IN-3 4.5±0.15 4.3±1.90 3.2±0.10 3.5±0.42

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ULK1-IN-3 相关抗体:

Cell Viability Assay[1]

Cell Line: 786-O, MCF-7, SW620 and T-24 colorectal cancer cells
Concentration: 0-20 μM
Incubation Time: 72 h
Result: Inhibited the viability of 786-O, MCF-7, SW620 and T-24 cancer cells by more than 80% at 20 μM.

Cell Cycle Analysis[1]

Cell Line: SW620 cells
Concentration: 1.25-10 μM
Incubation Time: 24 h
Result: Induced G2/M and S phase cell arrest and decreased the proportion of cells in the G0/G1 phase in SW620 cells.

Western Blot Analysis[1]

Cell Line: SW620 cells
Concentration: 1.25-5 μM
Incubation Time: 48 h
Result: Up-regulated cleaved PARP (cPARP) and the expression of NFκβ and AMPK, enhanced the availability of pro-apoptotic BCL-2 agonist of cell death (BAD) and multidomain effector protein BCL-2 antagonist/killer (BAK), increased autophagy marker light chain 3B (LC3B) lipidation, but down-regulated the expression of the AKT in SW620 cells.
分子量

436.88

Formula

C25H21ClO5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ULK1-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ULK1-IN-3ULKApoptosisPARPAutophagyNF-κBAMPKAktReactive Oxygen SpeciesUnc-51 like kinasepoly ADP ribose polymerase Nuclear factor-κBNuclear factor-kappaBAMP-activated protein kinasePKBProtein kinase BchromoneULK1growth inhibitorcell cycleautophagyapoptosiscolorectal cancer cellscolon cancerInhibitorinhibitorinhibit

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