ANAPC2 - anaphase promoting complex subunit 2 Gene

中文名称：后期促进复合亚基 2

种属: Homo sapiens

同用名: APC2

关于 ANAPC2

功能概要

一种称为后期促进复合物 (APC) 或环状体的大型蛋白质复合物通过泛素化其特定底物 (如有丝分裂细胞周期蛋白和后期抑制剂) 来促进中期-后期转变，这些底物随后被 26S 蛋白酶体降解。生化研究表明，脊椎动物 APC 包含八个亚基。 APC 的组成在从酵母到人类的生物体中高度保守。该基因的产物是复合物的一个组成部分，与最近发现的称为 cullins 的蛋白质家族具有序列相似性，后者也可能参与泛素介导的降解。[RefSeq 提供，2008 年 7 月]

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S Proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]