PAXIP1 - PAX interacting protein 1 Gene

中文名称：PAX 相互作用蛋白 1

种属: Homo sapiens

同用名: PTIP; TNRC2; CAGF28; CAGF29; PACIP1; PAXIP1L

基因 ID: 22976 | 基因类型: protein coding

关于 PAXIP1

Cytogenetic location: 7q36.2 Genomic coordinates (GRCh38): 7:154,943,690-155,003,411 (from NCBI)

This gene has 9 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 6.7), lymph node (RPKM 3.6) and 25 other tissues.

功能概要

该基因是配对盒 (PAX) 基因家族的成员，编码具有六个 BRCT (乳腺癌羧基末端) 结构域的核蛋白。这种蛋白质在维持基因组稳定性、染色质浓缩和有丝分裂进展方面起着关键作用。[RefSeq 提供，2008 年 7 月]

This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast Cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. [provided by RefSeq, Jul 2008]

PAXIP1 基因产物(1)

mRNA	Protein	Name
NM_007349.4	NP_031375.3	PAX-interacting protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11940591	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response, signal transduction by p53 class mediator	IMP IMP: 通过突变表型推断	15456759	GOA
involved in chromatin remodeling	IDA IDA: 通过直接分析推断	17178841	GOA
involved in negative regulation of DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	11940591	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IMP IMP: 通过突变表型推断	17925232	GOA
involved in response to ionizing radiation	IDA IDA: 通过直接分析推断	15456759	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of MLL3/4 complex	IDA IDA: 通过直接分析推断	17500065	GOA
part of MLL3/4 complex	IPI IPI: 通过物理相互作用推断	23508102	GOA
part of histone methyltransferase complex	IDA IDA: 通过直接分析推断	17925232	GOA
located in nucleus	IDA IDA: 通过直接分析推断	15456759	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PAXIP1 蛋白结构

PTCB-BRCT

BRCT

PTCB-BRCT

BRCT

0
200
400
600
800
1000
1069 a.a.

蛋白主名

其他名称

PAX-interacting protein 1

PAX interacting (with transcription-activation domain) protein 1

PAXIP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PAXIP1	Q6ZW49	PAGR1	Homo sapiens	Q9BTK6	Anti Bait CoIP	19124460
Intra	PAXIP1	Q6ZW49	PAGR1	Homo sapiens	Q9BTK6	Anti Bait CoIP	17178841
Intra	PAXIP1	Q6ZW49	PAGR1	Homo sapiens	Q9BTK6	GMS	19124460
Intra	PAXIP1	Q6ZW49	TP53BP1	Homo sapiens	Q12888	Pull Down	14576432
Intra	PAXIP1	Q6ZW49	TP53BP1	Homo sapiens	Q12888	Anti Bait CoIP	15456759
Intra	PAXIP1	Q6ZW49	ASH2L	Homo sapiens	Q9UBL3	Anti Bait CoIP	17178841
Intra	PAXIP1	Q6ZW49	ASH2L	Homo sapiens	Q9UBL3	Anti Bait CoIP	17500065
Intra	PAXIP1	Q6ZW49	ASH2L	Homo sapiens	Q9UBL3	Anti Bait CoIP	17925232
Intra	PAXIP1	Q6ZW49	WDR5	Homo sapiens	P61964	Anti Bait CoIP	17178841
Intra	PAXIP1	Q6ZW49	WDR5	Homo sapiens	P61964	Anti Bait CoIP	17925232
Intra	PAXIP1	Q6ZW49	RBBP5	Homo sapiens	Q15291	Anti Bait CoIP	17178841
Intra	PAXIP1	Q6ZW49	RBBP5	Homo sapiens	Q15291	Anti Bait CoIP	17500065
Intra	PAXIP1	Q6ZW49	RBBP5	Homo sapiens	Q15291	Anti Bait CoIP	17925232

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Kabuki Syndrome 1

Kabuki Syndrome	Niikawa-Kuroki Syndrome
Kabuki Make-Up Syndrome	Kms
KABUK1	Kabuki Make Up Syndrome
Nks	Kabuki Makeup Syndrome
Kabuki Syndrome, Type 1

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10098	PAXIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PAXIP1	RGD	RGD:1307547
Canis familiaris	PAXIP1	VGNC	VGNC:44282
Mus musculus	PAXIP1	MGD	MGI:1890430
Bos taurus	PAXIP1	VGNC	VGNC:32602
Macaca mulatta	PAXIP1	VGNC	VGNC:75769
Felis catus	PAXIP1	VGNC	VGNC:68704

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