NASP - nuclear autoantigenic sperm protein Gene

中文名称：核自身抗原精子蛋白

种属: Homo sapiens

同用名: HMDRA1; FLB7527; PRO1999

关于 NASP

功能概要

该基因编码一种 H1 组蛋白结合蛋白，该蛋白参与将组蛋白转运到分裂细胞的细胞核中。多种亚型由该基因的转录变体编码。体细胞形式在所有有丝分裂细胞中表达，定位于细胞核，并与细胞周期相关。睾丸形式在胚胎组织、肿瘤细胞和睾丸中表达。在雄性生殖细胞中，这种蛋白质定位于初级精母细胞的细胞质、精子细胞的细胞核和成熟精子的顶体周围区域。[RefSeq 提供，2008 年 7 月]

This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]