MT3 - metallothionein 3 Gene

中文名称：金属硫蛋白 3

种属: Homo sapiens

同用名: GIF; GIFB; GRIF; ZnMT3

基因 ID: 4504 | 基因类型: protein coding

关于 MT3

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,589,528-56,591,085 (from NCBI)

This gene has 6 transcripts (splice variants), 188 orthologues and 11 paralogues. Biased expression in brain (RPKM 149.3) and adrenal (RPKM 10.1).

功能概要

该基因是金属硫蛋白基因家族的成员。该基因家族编码的蛋白质分子量低，富含半胱氨酸，不含芳香族残基，可结合二价重金属离子。该基因家族成员表现出组织特异性表达，并且相对于其他基因家族成员编码的蛋白质，在其 N 末端附近包含一个苏氨酸插入片段，在其 C 末端附近包含一个富含谷氨酸的六肽插入片段。它在锌和铜稳态中起重要作用，并在缺氧条件下被诱导。编码的蛋白质是一种生长抑制因子，在患有某些与金属相关的神经退行性疾病 (例如阿尔茨海默氏病) 的个体的大脑中观察到蛋白质水平降低。[RefSeq 提供，2017 年 9 月]

This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tissue-specific expression, and contains a threonine insert near its N-terminus and a glutamate-rich hexapeptide insert near its C-terminus relative to the proteins encoded by Other gene family members. It plays an important role in zinc and copper homeostasis, and is induced under hypoxic conditions. The encoded protein is a growth inhibitory factor, and reduced levels of the protein are observed in the brains of individuals with some metal-linked neurodegenerative disorders such as Alzheimer's disease. [provided by RefSeq, Sep 2017]

MT3 基因产物(1)

mRNA	Protein	Name
NM_005954.4	NP_005945.1	metallothionein-3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cadmium ion binding	IDA IDA: 通过直接分析推断	16601975	GOA
enables copper ion binding	IDA IDA: 通过直接分析推断	21320589	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20646067	GOA
enables protein kinase activator activity	IDA IDA: 通过直接分析推断	18295594	GOA
enables zinc ion binding	IDA IDA: 通过直接分析推断	17712581	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in activation of protein kinase B activity	IDA IDA: 通过直接分析推断	18295594	GOA
involved in cellular detoxification	IDA IDA: 通过直接分析推断	18554677	GOA
involved in cellular response to hypoxia	IEP IEP: 通过表达模式推断	18206644	GOA
involved in cellular response to oxidative stress	IEP IEP: 通过表达模式推断	20039155	GOA
involved in cellular response to reactive oxygen species	IDA IDA: 通过直接分析推断	18554677	GOA
involved in negative regulation of axon extension	IDA IDA: 通过直接分析推断	16601975	GOA
involved in negative regulation of cell growth	IDA IDA: 通过直接分析推断	16601975	GOA
involved in negative regulation of cell growth	IMP IMP: 通过突变表型推断	16945328	GOA
involved in negative regulation of oxidoreductase activity	IDA IDA: 通过直接分析推断	21320589	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	18295594	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: 通过直接分析推断	18295594	GOA
involved in positive regulation of gene expression	IDA IDA: 通过直接分析推断	18295594	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: 通过直接分析推断	18295594	GOA
involved in positive regulation of vascular endothelial growth factor receptor signaling pathway	IDA IDA: 通过直接分析推断	18295594	GOA
involved in protein stabilization	IDA IDA: 通过直接分析推断	18295594	GOA
involved in removal of superoxide radicals	IDA IDA: 通过直接分析推断	12383939	GOA
involved in response to hypoxia	IDA IDA: 通过直接分析推断	12763630	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	10355541	GOA
located in inclusion body	IDA IDA: 通过直接分析推断	20039155	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	20039155	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MT3 蛋白结构

Metallothio

0
68 a.a.

蛋白主名

其他名称

metallothionein-3

growth inhibitory factor

MT3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MT3	P25713	TTR	Homo sapiens	P02766	Anti Tag CoIP	20646067
种属内	MT3	P25713	TTR	Homo sapiens	P02766	Saturation Binding	20646067
种属内	MT3	P25713	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Milker'S Nodule

Poxviridae Infections	Milker Nodule
Milkers' Node	Paravaccinia
Pseudocowpox	Milker'S Nodes

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Menkes Disease

Copper Transport Disease	Menkes Syndrome
MNK	Kinky Hair Disease
Steely Hair Disease	Menkes Kinky-Hair Syndrome
Mk	Steely Hair Syndrome
Menkea Syndrome	Md
Menkes Kinky Hair Syndrome	Hypocupremia, Congenital
Kinky Hair Syndrome	X-Linked Copper Deficiency
Menkes Kinky Hair Disease

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-128206	I3MT-3	Inhibitor	99.98%	否
HY-P5846	Muscarinic toxin 3	Antagonist	/	否
HY-RS08744	MT3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-101303	5-MCA-NAT	Agonist	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	MT3	RGD	RGD:621252
Mus musculus	MT3	MGD	MGI:97173
Bos taurus	MT3	VGNC	VGNC:52208
Others	MT3	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MT3 - metallothionein 3 Gene

关于 MT3

功能概要

MT3 基因产物(1)

MT3 蛋白结构

MT3 蛋白互作信息

关联疾病

直系同源

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MT3 - metallothionein 3 Gene

关于 MT3

功能概要

MT3 基因产物(1)

MT3 蛋白结构

MT3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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Z