PPP2R1B - protein phosphatase 2 scaffold subunit Abeta Gene

中文名称：蛋白磷酸酶 2 支架亚基 Abeta

种属: Homo sapiens

同用名: PR65B; PP2A-Abeta

基因 ID: 5519 | 基因类型: protein coding

关于 PPP2R1B

Cytogenetic location: 11q23.1 Genomic coordinates (GRCh38): 11:111,688,000-111,766,389 (from NCBI)

This gene has 12 transcripts (splice variants), 192 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 13.7), fat (RPKM 13.4) and 25 other tissues.

功能概要

该基因编码蛋白磷酸酶 2 的恒定调节亚基。蛋白磷酸酶 2 是四种主要的 Ser/Thr 磷酸酶之一，与细胞生长和分裂的负调控有关。它由一个共同的异聚核心酶组成，该核心酶由一个催化亚基和一个恒定的调节亚基组成，与多种调节亚基相关联。恒定调节亚基 A 作为支架分子协调催化亚基和可变调节 B 亚基的组装。该基因编码恒定调节亚基 A 的 β 亚型。该基因的突变与某些肺癌和结肠癌有关。已经描述了选择性剪接的转录物变体。[RefSeq 提供，2010 年 4 月]

This gene encodes a constant regulatory subunit of protein Phosphatase 2. Protein Phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core Enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

PPP2R1B 基因产物(5)

mRNA	Protein	Name
NM_001177562.2	NP_001171033.1	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform d
NM_001177563.2	NP_001171034.1	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform e
NM_002716.5	NP_002707.3	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform a
NM_181699.3	NP_859050.1	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform b
NM_181700.2	NP_859051.1	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform c

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	8392071	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in apoptotic process involved in morphogenesis	IMP IMP: 通过突变表型推断	21172653	GOA
involved in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: 通过突变表型推断	21172653	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in membrane raft	IDA IDA: 通过直接分析推断	21172653	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP2R1B 蛋白结构

HEAT

HEAT_2

0
100
200
300
400
500
601 a.a.

蛋白主名

其他名称

serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

protein phosphatase 2, regulatory subunit A, beta

关联疾病

疾病名称

别名

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Cervical Cancer

Cervical Cancer, Somatic	Neoplasm Of Uterine Cervix
Cervix Cancer	Uterine Cervical Neoplasm
Cervical Neoplasm	Cervix Uteri Cancer
Tumor Of The Cervix Uteri	CERCA
Uterine Cervical Cancer	Neoplasms Cervical
Uterine Cervical Neoplasms	Cervical Cancers
Cancer, Cervical, Somatic	Malignant Tumor Of Cervix
Cervix Carcinoma

Hereditary Wilms' Tumor

Hereditary Wilms Tumor	Hereditary Wilms Tumour
Hereditary Wilms' Tumour	Wt1

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11010	PPP2R1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PPP2R1B	MGD	MGI:1920949
Rattus norvegicus	PPP2R1B	RGD	RGD:1304764
Macaca mulatta	PPP2R1B	VGNC	VGNC:76375
Felis catus	PPP2R1B	VGNC	VGNC:69010
Bos taurus	PPP2R1B	VGNC	VGNC:33254
Canis familiaris	PPP2R1B	VGNC	VGNC:44906

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PPP2R1B - protein phosphatase 2 scaffold subunit Abeta Gene

关于 PPP2R1B

功能概要

PPP2R1B 基因产物(5)

PPP2R1B 蛋白结构

关联疾病

直系同源

热门区域

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PPP2R1B - protein phosphatase 2 scaffold subunit Abeta Gene

关于 PPP2R1B

功能概要

PPP2R1B 基因产物(5)

PPP2R1B 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z