1. Gene
  2. RALA - RAS like proto-oncogene A Gene

RALA - RAS like proto-oncogene A Gene

中文名称:RAS 样原癌基因 A

种属: Homo sapiens

同用名: RAL; HINCONS

基因 ID: 5898 | 基因类型: protein coding

关于 RALA

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:39,623,572-39,708,120 (from NCBI)

This gene has 5 transcripts (splice variants), 225 orthologues, 35 paralogues and is associated with 2 phenotypes. Ubiquitous expression in esophagus (RPKM 22.0), lung (RPKM 20.7) and 25 other tissues.

功能概要

该基因的产物属于小 GTPase 超家族,Ras 蛋白家族。 GTP 结合蛋白介导由某些细胞表面受体的占据启动的跨膜信号传导。该基因编码一种低分子量的 Ras 样 GTP 结合蛋白,与其他 Ras 蛋白具有约 50% 的相似性。[RefSeq 提供,2008 年 7 月]

The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with Other ras proteins. [provided by RefSeq, Jul 2008]

RALA 基因产物(1)

mRNA Protein Name
NM_005402.4 NP_005393.2 ras-related protein Ral-A precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATPase binding IPI
IPI: 通过物理相互作用推断
24056301 GOA
enables Edg-2 lysophosphatidic acid receptor binding IDA
IDA: 通过直接分析推断
19306925 GOA
enables GDP binding IDA
IDA: 通过直接分析推断
24056301 GOA
enables GTP binding IDA
IDA: 通过直接分析推断
24056301 GOA
enables GTPase activity IMP
IMP: 通过突变表型推断
30500825 GOA
enables myosin binding IPI
IPI: 通过物理相互作用推断
24056301 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7673236 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
24056301 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Ras protein signal transduction IMP
IMP: 通过突变表型推断
30500825 GOA
involved in establishment of protein localization to mitochondrion IMP
IMP: 通过突变表型推断
21822277 GOA
involved in membrane raft localization IDA
IDA: 通过直接分析推断
20005108 GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
34096503 GOA
involved in positive regulation of filopodium assembly IDA
IDA: 通过直接分析推断
10051605 GOA
involved in positive regulation of mitochondrial fission IMP
IMP: 通过突变表型推断
21822277 GOA
involved in receptor internalization IGI
IGI: 通过遗传相互作用推断
34096503 GOA
involved in regulation of actin cytoskeleton organization IDA
IDA: 通过直接分析推断
10051605 GOA
involved in regulation of exocytosis IDA
IDA: 通过直接分析推断
20005108 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
19306925 GOA
located in cleavage furrow IDA
IDA: 通过直接分析推断
18756269 GOA
colocalizes with endocytic vesicle IDA
IDA: 通过直接分析推断
19306925 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
21822277 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
17875936 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RALA 蛋白结构

Ras

Ras: Ras family (16 - 176)

  • 0
  • 100
  • 206 a.a.
蛋白主名 其他名称

ras-related protein Ral-A

RALA Ras like proto-oncogene A

RALA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RALA P11233 HRAS Homo sapiens P01112 19222999
种属内
RALA P11233 PPP2R1B Homo sapiens P30154 17540176
种属内
RALA P11233 RALBP1 Homo sapiens Q15311
PLA
25241761
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hiatt-Neu-Cooper Neurodevelopmental Syndrome

HINCONS

Laryngeal Tuberculosis

Tuberculosis, Laryngeal

Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Ras-Associated Autoimmune Leukoproliferative Disorder

RALD

Autoimmune Lymphoproliferative Syndrome Type 4

Alps4

Autoimmune Lymphoproliferative Syndrome, Type Iv

Ras-Associated Autoimmune Leukoproliferative Disease

Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic

Alps Type 4

Alps Type Iv

Autoimmune Lymphoproliferative Syndrome Type Iv

Autoimmune Lymphoproliferative Syndrome 4

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus RALA VGNC VGNC:69227
Macaca mulatta RALA VGNC VGNC:108434
Bos taurus RALA VGNC VGNC:33698
Canis familiaris RALA VGNC VGNC:45330
Mus musculus RALA MGD MGI:1927243
Rattus norvegicus RALA RGD RGD:619851