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  2. PPP2R5C - protein phosphatase 2 regulatory subunit B'gamma Gene

PPP2R5C - protein phosphatase 2 regulatory subunit B'gamma Gene

中文名称:蛋白磷酸酶 2 调节亚基 B'gamma

种属: Homo sapiens

同用名: B56G; PR61G; B56gamma

基因 ID: 5527 | 基因类型: protein coding

关于 PPP2R5C

Cytogenetic location: 14q32.31 Genomic coordinates (GRCh38): 14:101,760,573-101,927,992 (from NCBI)

This gene has 33 transcripts (splice variants), 199 orthologues and 4 paralogues. Ubiquitous expression in lymph node (RPKM 21.8), testis (RPKM 19.2) and 25 other tissues.

功能概要

该基因的产物属于磷酸酶 2A 调节亚基 B 家族。蛋白磷酸酶 2A 是四种主要的 Ser/Thr 磷酸酶之一,与细胞生长和分裂的负调控有关。它由一个共同的异聚核心酶组成,该核心酶由一个催化亚基和一个恒定的调节亚基组成,与多种调节亚基相关联。 B 调节亚基可能调节底物选择性和催化活性。该基因编码调节亚基 B56 亚家族的 γ 异构体。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供,2008 年 7 月]

The product of this gene belongs to the Phosphatase 2A regulatory subunit B family. Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core Enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PPP2R5C 基因产物(10)

mRNA Protein Name
NM_001161725.2 NP_001155197.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform e
NM_001161726.2 NP_001155198.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform f
NM_001352912.1 NP_001339841.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform b
NM_001352913.2 NP_001339842.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform g
NM_001352914.2 NP_001339843.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform h
NM_001352915.2 NP_001339844.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform j
NM_001352916.2 NP_001339845.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform i
NM_002719.4 NP_002710.2 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform a
NM_178586.3 NP_848701.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform b
NM_178587.3 NP_848702.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform c

PPP2R5C 蛋白结构

B56

B56: Protein phosphatase 2A regulatory B subunit (B56 family) (30 - 438)

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  • 524 a.a.
蛋白主名 其他名称

serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

B' alpha regulatory subunit

关联疾病

疾病名称 别名
Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis

Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome

Mva Syndrome

Mosaic Variegated Aneuplody Microcephaly Syndrome

Warburton Anyane Yeboa Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus PPP2R5C VGNC VGNC:33262
Mus musculus PPP2R5C MGD MGI:1349475
Canis familiaris PPP2R5C VGNC VGNC:44915
Rattus norvegicus PPP2R5C RGD RGD:1585097
Felis catus PPP2R5C VGNC VGNC:69017