PPP2R2A - protein phosphatase 2 regulatory subunit Balpha Gene

中文名称：蛋白磷酸酶 2 调节亚基 Balpha

种属: Homo sapiens

同用名: B55A; PR52A; PR55A; B55ALPHA; PR55alpha

基因 ID: 5520 | 基因类型: protein coding

关于 PPP2R2A

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:26,291,508-26,372,680 (from NCBI)

This gene has 28 transcripts (splice variants), 141 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 15.8), placenta (RPKM 12.6) and 25 other tissues.

功能概要

该基因的产物属于磷酸酶 2 调节亚基 B 家族。蛋白磷酸酶 2 是四种主要的 Ser/Thr 磷酸酶之一，与细胞生长和分裂的负调控有关。它由一个共同的异聚核心酶组成，该核心酶由一个催化亚基和一个恒定的调节亚基组成，与多种调节亚基相关联。 B 调节亚基可能调节底物选择性和催化活性。该基因编码调节亚基 B55 亚家族的 alpha 异构体。已经描述了选择性剪接的转录物变体。[RefSeq 提供，2010 年 4 月]

The product of this gene belongs to the Phosphatase 2 regulatory subunit B family. Protein Phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core Enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

PPP2R2A 基因产物(2)

mRNA	Protein	Name
NM_001177591.2	NP_001171062.1	serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 2
NM_002717.4	NP_002708.1	serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	9847399	GOA
enables protein phosphatase regulator activity	IDA IDA: 通过直接分析推断	1849734	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in protein dephosphorylation	IDA IDA: 通过直接分析推断	1849734	GOA
involved in protein dephosphorylation	IMP IMP: 通过突变表型推断	33108758	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of protein phosphatase type 2A complex	IDA IDA: 通过直接分析推断	1849734	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

protein phosphatase 2, regulatory subunit B, alpha

PPP2R2A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PPP2R2A	P63151	LRP1B	Homo sapiens	Q9NZR2	Validated Y2H	32814053
种属内	PPP2R2A	P63151	LRP1B	Homo sapiens	Q9NZR2	Y2H Pooling	32814053
种属内	PPP2R2A	P63151	LRP1B	Homo sapiens	Q9NZR2	Y2H Array	32814053
种属内	PPP2R2A	P63151	COL25A1	Homo sapiens	Q8NE08	Y2H Array	32814053
种属内	PPP2R2A	P63151	COL25A1	Homo sapiens	Q8NE08	Y2H Pooling	32814053
种属内	PPP2R2A	P63151	COL25A1	Homo sapiens	Q8NE08	Validated Y2H	32814053
种属内	PPP2R2A	P63151	PPP2R1A	Homo sapiens	P30153	Pull Down	20711181
种属内	PPP2R2A	P63151	PPP2R1A	Homo sapiens	P30153	BioID	28330616
种属内	PPP2R2A	P63151	PPP2R1A	Homo sapiens	P30153	Pull Down	28330616
种属内	PPP2R2A	P63151	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	26496610
种属内	PPP2R2A	P63151	PPP2R1B	Homo sapiens	P30154	BioID	28330616
种属内	PPP2R2A	P63151	PPP2R1B	Homo sapiens	P30154	Pull Down	28330616
种属内	PPP2R2A	P63151	PPP2R1B	Homo sapiens	P30154	Anti Tag CoIP	26496610
种属内	PPP2R2A	P63151	NEDD8	Homo sapiens	Q15843	Validated Y2H	32814053
种属内	PPP2R2A	P63151	NEDD8	Homo sapiens	Q15843	Y2H Array	32814053
种属内	PPP2R2A	P63151	NEDD8	Homo sapiens	Q15843	Y2H Pooling	32814053
种属内	PPP2R2A	P63151	FBXL20	Homo sapiens	Q96IG2	Anti Bait CoIP	34731788
种属内	PPP2R2A	P63151	FBXL20	Homo sapiens	Q96IG2	Confocal	34731788

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11011	PPP2R2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	PPP2R2A	VGNC	VGNC:33255
Mus musculus	PPP2R2A	MGD	MGI:1919228
Macaca mulatta	PPP2R2A	VGNC	VGNC:84103
Canis familiaris	PPP2R2A	VGNC	VGNC:44907
Felis catus	PPP2R2A	VGNC	VGNC:69011
Rattus norvegicus	PPP2R2A	RGD	RGD:620919

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PPP2R2A - protein phosphatase 2 regulatory subunit Balpha Gene

关于 PPP2R2A

功能概要

PPP2R2A 基因产物(2)

PPP2R2A 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

PPP2R2A - protein phosphatase 2 regulatory subunit Balpha Gene

关于 PPP2R2A

功能概要

PPP2R2A 基因产物(2)

PPP2R2A 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z