1. Gene
  2. PPP2R5B - protein phosphatase 2 regulatory subunit B'beta Gene

PPP2R5B - protein phosphatase 2 regulatory subunit B'beta Gene

中文名称:蛋白磷酸酶 2 调节亚基 B'beta

种属: Homo sapiens

同用名: B56B; PR61B; B56beta

基因 ID: 5526 | 基因类型: protein coding

关于 PPP2R5B

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,917,573-64,934,475 (from NCBI)

This gene has 5 transcripts (splice variants), 190 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 15.1), gall bladder (RPKM 6.6) and 25 other tissues.

功能概要

该基因的产物属于磷酸酶 2A 调节亚基 B 家族。蛋白磷酸酶 2A 是四种主要的 Ser/Thr 磷酸酶之一,与细胞生长和分裂的负调控有关。它由一个共同的异聚核心酶组成,该核心酶由一个催化亚基和一个恒定的调节亚基组成,与多种调节亚基相关联。 B 调节亚基可能调节底物选择性和催化活性。该基因编码调节亚基 B56 亚家族的 β 亚型。[RefSeq 提供,2008 年 7 月]

The product of this gene belongs to the Phosphatase 2A regulatory subunit B family. Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core Enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008]

PPP2R5B 基因产物(1)

mRNA Protein Name
NM_006244.4 NP_006235.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
7592815 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PPP2R5B 蛋白结构

B56

B56: Protein phosphatase 2A regulatory B subunit (B56 family) (61 - 467)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 497 a.a.
蛋白主名 其他名称

serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

protein phosphatase 2 regulatory subunit B', beta

PPP2R5B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PPP2R5B Q15173 CHEK2 Homo sapiens O96017
Pull Down
15380617
种属内
PPP2R5B Q15173 IER3 Homo sapiens P46695
Anti Tag CoIP
16456541
种属内
PPP2R5B Q15173 IER3 Homo sapiens P46695
Pull Down
16456541
种属内
PPP2R5B Q15173 PPP2R1A Homo sapiens P30153
Y2H Prey Pooling
32296183
种属内
PPP2R5B Q15173 PPP2R1A Homo sapiens P30153
Y2H Array
32296183
种属内
PPP2R5B Q15173 PPP2CA Homo sapiens P67775
Y2H
7592815
种属内
PPP2R5B Q15173 PPP2CA Homo sapiens P67775
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spinocerebellar Ataxia 30

Spinocerebellar Ataxia Type 30

SCA30

Cerebellar Ataxia Early-Onset Nonprogressive

Spinocerebellar Ataxia 29

Acv

Aplasia Of Cerebellar Vermis

Cerebellar Vermis Aplasia

Congenital Nonprogressive Spinocerebellar Ataxia

Sca29

Spinocerebellar Ataxia Type 29

Spinocerebellar Ataxia 25

Spinocerebellar Ataxia Type 25

SCA25

Spinocerebellar Ataxia 21

Spinocerebellar Ataxia Type 21

SCA21

Ataxia, Spinocerebellar, Type 21

Spinocerebellar Ataxia 20

Spinocerebellar Ataxia Type 20

SCA20

Spinocerebellar Ataxia With Dysphonia

Spinocerebellar Ataxia With Spasmodic Cough

Chromosome 11q12 Duplication Syndrome, 260-Kb

Chromosome 11q12 Duplication Syndrome 260-Kb

Spinocerebellar Ataxia 12

Spinocerebellar Ataxia Type 12

SCA12

Ataxia, Spinocerebellar, Type 12

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus PPP2R5B VGNC VGNC:69016
Bos taurus PPP2R5B VGNC VGNC:33261
Rattus norvegicus PPP2R5B RGD RGD:727786
Mus musculus PPP2R5B MGD MGI:2388480
Macaca mulatta PPP2R5B VGNC VGNC:101383
Canis familiaris PPP2R5B VGNC VGNC:44914