RNF7 - ring finger protein 7 Gene

中文名称：无名指蛋白 7

种属: Homo sapiens

同用名: SAG; ROC2; rbx2; CKBBP1

基因 ID: 9616 | 基因类型: protein coding

关于 RNF7

Cytogenetic location: 3q23 Genomic coordinates (GRCh38): 3:141,738,298-141,747,560 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 15.8), adrenal (RPKM 15.8) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种高度保守的无名指蛋白。它是 SKP1-cullin/CDC53-F 盒蛋白泛素连接酶的重要亚基，泛素连接酶是对细胞周期进程和信号转导很重要的蛋白质降解机制的一部分。这种蛋白质与酪蛋白激酶 II (CSNK2A1/CKII) 相互作用，并且是其底物。 CSNK2A1 对该蛋白质的磷酸化已显示可促进 IkappaBalpha (CHUK/IKK-alpha/IKBKA) 和 p27Kip1 (CDKN1B) 的降解。已经报道了编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, Casein Kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

RNF7 基因产物(3)

mRNA	Protein	Name
NM_001201370.2	NP_001188299.1	RING-box protein 2 isoform 4
NM_014245.5	NP_055060.1	RING-box protein 2 isoform 1
NM_183237.3	NP_899060.1	RING-box protein 2 isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables NEDD8 ligase activity	IDA IDA: 通过直接分析推断	19250909	GOA
enables cullin family protein binding	IDA IDA: 通过直接分析推断	10230407	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16325183	GOA
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	16874460	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in endoplasmic reticulum unfolded protein response	IDA IDA: 通过直接分析推断	31387940	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	21980433	GOA
involved in protein K11-linked ubiquitination	IDA IDA: 通过直接分析推断	27910872	GOA
involved in protein neddylation	IDA IDA: 通过直接分析推断	19250909	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Cul5-RING ubiquitin ligase complex	IDA IDA: 通过直接分析推断	21980433	GOA
is active in cytoplasm	IDA IDA: 通过直接分析推断	16874460	GOA
is active in nucleus	IDA IDA: 通过直接分析推断	16874460	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RNF7 蛋白结构

zf-rbx1

0
100
113 a.a.

蛋白主名

其他名称

RING-box protein 2

CKII beta-binding protein 1

RNF7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RNF7	Q9UBF6	CUL5	Homo sapiens	Q93034	Y2H Array	25416956
种属内	RNF7	Q9UBF6	CUL5	Homo sapiens	Q93034	Anti Tag CoIP	33961781
种属内	RNF7	Q9UBF6	CUL5	Homo sapiens	Q93034	Validated Y2H	25416956
种属内	RNF7	Q9UBF6	ASB1	Homo sapiens	Q9Y576	Anti Tag CoIP	33961781
种属内	RNF7	Q9UBF6	ASB7	Homo sapiens	Q9H672	Anti Tag CoIP	33961781
种属内	RNF7	Q9UBF6	ASB6	Homo sapiens	Q9NWX5	Anti Tag CoIP	33961781
种属内	RNF7	Q9UBF6	IKBKG	Homo sapiens	Q9Y6K9	Pull Down	20098747
种属内	RNF7	Q9UBF6	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	20098747
种属内	RNF7	Q9UBF6	IKBKG	Homo sapiens	Q9Y6K9	Y2H	20098747

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Brachydactyly, Type E2

Brachydactyly Type E2	BDE2
Brachydactyly E2

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Cockayne Syndrome A

Cockayne Syndrome Type 1	Cockayne Syndrome, Type A
Cockayne Syndrome Type I	CSA
Cockayne Syndrome Classic Form	Cockayne Syndrome Classical
Cockayne Syndrome Type A	Ckn1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12096	RNF7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	RNF7	MGD	MGI:1337096
Canis familiaris	RNF7	VGNC	VGNC:45675
Macaca mulatta	RNF7	VGNC	VGNC:76707
Bos taurus	RNF7	VGNC	VGNC:34072
Felis catus	RNF7	VGNC	VGNC:102814
Rattus norvegicus	RNF7	RGD	RGD:1311048
Others	RNF7	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RNF7 - ring finger protein 7 Gene

关于 RNF7

功能概要

RNF7 基因产物(3)

RNF7 蛋白结构

RNF7 蛋白互作信息

关联疾病

直系同源

热门区域

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RNF7 - ring finger protein 7 Gene

关于 RNF7

功能概要

RNF7 基因产物(3)

RNF7 蛋白结构

RNF7 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z